(rac)-2-amino-2-(4-(4-(3-(tert-butyl)-4-(isopropylamino)phenyl)pyrimidin-2-yl)phenyl)ethanol

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Chemical Name:(rac)-2-amino-2-(4-(4-(3-(tert-butyl)-4-(isopropylamino)phenyl)pyrimidin-2-yl)phenyl)ethanol
CAS No.:1378365-65-1
Molecular Formula:C₂₅H₃₂N₄O
Molecular Weight:404.555
Hs Code.:

Synonyms:(rac)-2-amino-2-(4-(4-(3-(tert-butyl)-4-(isopropylamino)phenyl)pyrimidin-2-yl)phenyl)ethanol

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Chemical Property of (rac)-2-amino-2-(4-(4-(3-(tert-butyl)-4-(isopropylamino)phenyl)pyrimidin-2-yl)phenyl)ethanol

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Technology Process of (rac)-2-amino-2-(4-(4-(3-(tert-butyl)-4-(isopropylamino)phenyl)pyrimidin-2-yl)phenyl)ethanol

There total 8 articles about (rac)-2-amino-2-(4-(4-(3-(tert-butyl)-4-(isopropylamino)phenyl)pyrimidin-2-yl)phenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1378368-32-1
(rac)-tert-butyl (1-(4-(4-(3-(tert-butyl)-4-(isopropylamino)phenyl)pyrimidin-2-yl)phenyl)-2-hydroxyethyl)carbamate

: 1378365-65-1
(rac)-2-amino-2-(4-(4-(3-(tert-butyl)-4-(isopropylamino)phenyl)pyrimidin-2-yl)phenyl)ethanol

Guidance literature:: (rac)-tert-butyl (1-(4-(4-(3-(tert-butyl)-4-(isopropylamino)phenyl)pyrimidin-2-yl)phenyl)-2-hydroxyethyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.166667h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 6310-21-0
2-(1,1-dimethylethyl)-benzenamine

: 1378365-65-1
(rac)-2-amino-2-(4-(4-(3-(tert-butyl)-4-(isopropylamino)phenyl)pyrimidin-2-yl)phenyl)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 60 °C / Inert atmosphere

2: tetra-N-butylammonium tribromide / tetrahydrofuran / 0 - 20 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C / Inert atmosphere

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 120 °C / Inert atmosphere; Sealed; microwave irradiation

6: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

With potassium acetate; tetra-N-butylammonium tribromide; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 179811-64-4
4-(aminomethyl)benzene-1,2-diol hydrochloride

: 1378365-65-1
(rac)-2-amino-2-(4-(4-(3-(tert-butyl)-4-(isopropylamino)phenyl)pyrimidin-2-yl)phenyl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 20 °C

2: potassium acetate; 1,3-diisopropyl-1H-imidazol-3-ium chloride / palladium diacetate / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 120 °C / Inert atmosphere; Sealed; microwave irradiation

4: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

With potassium acetate; sodium carbonate; triethylamine; trifluoroacetic acid; 1,3-diisopropyl-1H-imidazol-3-ium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;