N-{3-[3-(aminomethyl)phenyl]-2,6-dimethylthieno[2,3-b]pyridin-4-yl}-3-chlorobenzenesulfonamide

Base Information

Chemical Name:N-{3-[3-(aminomethyl)phenyl]-2,6-dimethylthieno[2,3-b]pyridin-4-yl}-3-chlorobenzenesulfonamide
CAS No.:1312593-51-3
Molecular Formula:C₂₂H₂₀ClN₃O₂S₂
Molecular Weight:458.005
Hs Code.:

Synonyms:N-{3-[3-(aminomethyl)phenyl]-2,6-dimethylthieno[2,3-b]pyridin-4-yl}-3-chlorobenzenesulfonamide

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Chemical Property of N-{3-[3-(aminomethyl)phenyl]-2,6-dimethylthieno[2,3-b]pyridin-4-yl}-3-chlorobenzenesulfonamide

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Technology Process of N-{3-[3-(aminomethyl)phenyl]-2,6-dimethylthieno[2,3-b]pyridin-4-yl}-3-chlorobenzenesulfonamide

There total 7 articles about N-{3-[3-(aminomethyl)phenyl]-2,6-dimethylthieno[2,3-b]pyridin-4-yl}-3-chlorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312593-50-2
1,1-dimethylethyl {[3-(4-{[(3-chlorophenyl)sulfonyl]amino}-2,6-dimethylthieno[2,3-b]pyridin-3-yl)phenyl]methyl}carbamate

: 1312593-51-3
N-{3-[3-(aminomethyl)phenyl]-2,6-dimethylthieno[2,3-b]pyridin-4-yl}-3-chlorobenzenesulfonamide

Guidance literature:: 1,1-dimethylethyl {[3-(4-{[(3-chlorophenyl)sulfonyl]amino}-2,6-dimethylthieno[2,3-b]pyridin-3-yl)phenyl]methyl}carbamate; With trifluoroacetic acid; In dichloromethane; for 1h;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 138564-58-6
2-amino-5-methylthiophene-3-carbonitrile

: 1312593-51-3
N-{3-[3-(aminomethyl)phenyl]-2,6-dimethylthieno[2,3-b]pyridin-4-yl}-3-chlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: tin(IV) chloride / toluene / 6 h / Reflux

1.2: Cooling

2.1: N-Bromosuccinimide / dichloromethane / 1 h

3.1: sodium hydroxide; water / ethanol / 1 h / 100 °C

3.2: pH 6 - 7

4.1: diphenylether / 4 h / 200 °C

5.1: potassium tert-butylate / tetrahydrofuran / 0.08 h

5.2: 1 h

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

7.1: trifluoroacetic acid / dichloromethane / 1 h

With N-Bromosuccinimide; potassium tert-butylate; water; tin(IV) chloride; potassium carbonate; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diphenylether; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1312593-41-1
N-(3-bromo-2,6-dimethylthieno[2,3-b]pyridin-4-yl)-3-chlorobenzenesulfonamide

: 1312593-51-3
N-{3-[3-(aminomethyl)phenyl]-2,6-dimethylthieno[2,3-b]pyridin-4-yl}-3-chlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

2: trifluoroacetic acid / dichloromethane / 1 h

With potassium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water;