[3-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid 3-[3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl ester

Base Information

• Chemical Name: [3-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid 3-[3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl ester
• CAS No.: 195510-93-1
• Molecular Formula: C₄₉H₅₉N₇O₈
• Molecular Weight: 874.05
• Mol file: 195510-93-1.mol

Synonyms:[3-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid 3-[3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl ester

Chemical Property of [3-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid 3-[3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid 3-[3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl ester

There total 7 articles about [3-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid 3-[3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine (73278-98-5) + 4-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyloxycarbonylamino}-3-(tetrahydro-pyran-2-yloxy)-butyric acid → [3-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid 3-[3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl ester (195510-93-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 16h; Ambient temperature;

DOI:10.1016/S0968-0896(97)00074-6

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → [3-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid 3-[3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl ester (195510-93-1)

Guidance literature:

Multi-step reaction with 3 steps

1: TsOH*H₂O / CH₂Cl₂ / 2 h / 20 °C

2: aq. NaOH / methanol / 2 h / 0 °C

3: 77 percent / 1-hydroxybenzotriazol, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(97)00074-6

Reference yield:

1-(3-Hydroxymethyl-phenyl)-3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea (153825-72-0) → [3-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid 3-[3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl ester (195510-93-1)

Guidance literature:

Multi-step reaction with 5 steps

1: (n-Bu₃Sn)2O

2: 85 percent / n-Bu₄NF / tetrahydrofuran / 3 h / Ambient temperature

3: TsOH*H₂O / CH₂Cl₂ / 2 h / 20 °C

4: aq. NaOH / methanol / 2 h / 0 °C

5: 77 percent / 1-hydroxybenzotriazol, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis(tri-n-butyltin)oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(97)00074-6

upstream raw materials:

N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine

3,4-dihydro-2H-pyran

1-(3-Hydroxymethyl-phenyl)-3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea

3-(tert-butyldimethylsilanyloxy)-4-isocyanatobutyric acid methyl ester