N,N-bis(2,4-dimethoxybenzyl)difluoro(4-formylphenyl)methanesulfonamide

Base Information

Chemical Name:N,N-bis(2,4-dimethoxybenzyl)difluoro(4-formylphenyl)methanesulfonamide
CAS No.:914927-68-7
Molecular Formula:C₂₆H₂₇F₂NO₇S
Molecular Weight:535.566
Hs Code.:

Synonyms:N,N-bis(2,4-dimethoxybenzyl)difluoro(4-formylphenyl)methanesulfonamide

Suppliers and Price of N,N-bis(2,4-dimethoxybenzyl)difluoro(4-formylphenyl)methanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N,N-bis(2,4-dimethoxybenzyl)difluoro(4-formylphenyl)methanesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N,N-bis(2,4-dimethoxybenzyl)difluoro(4-formylphenyl)methanesulfonamide

There total 1 articles about N,N-bis(2,4-dimethoxybenzyl)difluoro(4-formylphenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 803727-99-3
N,N-bis(2,4-dimethoxybenzyl)-1,1-difluoro-1-(4-iodophenyl)methanesulfonamide

: 914927-68-7
N,N-bis(2,4-dimethoxybenzyl)difluoro(4-formylphenyl)methanesulfonamide

Guidance literature:: N,N-bis(2,4-dimethoxybenzyl)-1,1-difluoro-1-(4-iodophenyl)methanesulfonamide; With n-butyllithium; In tetrahydrofuran;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 0.25h;
DOI:10.1021/jo061496r

Reference yield: 90.0%

: 914927-68-7
N,N-bis(2,4-dimethoxybenzyl)difluoro(4-formylphenyl)methanesulfonamide

: 914927-69-8
N,N-bis(2,4-dimethoxybenzyl)difluoro(4-(hydroxymethyl)phenyl)methanesulfonamide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 1h;
DOI:10.1021/jo061496r

Reference yield:

: 914927-68-7
N,N-bis(2,4-dimethoxybenzyl)difluoro(4-formylphenyl)methanesulfonamide

: (S)-2-Amino-3-(4-{[bis-(2,4-dimethoxy-benzyl)-sulfamoyl]-difluoro-methyl}-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / NaBH₄ / methanol; tetrahydrofuran / 1 h / 0 °C

2: 95 percent / CBr₄; triphenylphosphine / CH₂Cl₂ / 0 - 20 °C

3: 80 percent / LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / -78 °C

4: hydrogen / PdCl₂ / ethanol; dioxane / 6.5 h

With sodium tetrahydroborate; carbon tetrabromide; hydrogen; triphenylphosphine; lithium hexamethyldisilazane; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane;
DOI:10.1021/jo061496r