(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}pyrazolesulfonylurea

Base Information

Chemical Name:(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}pyrazolesulfonylurea
CAS No.:1239362-55-0
Molecular Formula:C₁₈H₁₈FN₇O
Molecular Weight:367.386
Hs Code.:

Synonyms:(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}pyrazolesulfonylurea

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Chemical Property of (S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}pyrazolesulfonylurea

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Technology Process of (S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}pyrazolesulfonylurea

There total 7 articles about (S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}pyrazolesulfonylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1239362-55-0
(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}pyrazolesulfonylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: diphenylphosphoranyl azide; triethylamine / Reflux

2.1: sodium t-butanolate / palladium diacetate / 1,4-dioxane / 10 h / 100 °C / Inert atmosphere

3.1: sodium t-butanolate; XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 100 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

5.1: dichloromethane / 20 °C

5.2: 20 °C

With diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; sodium t-butanolate; XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; palladium diacetate; In 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: C₂₁H₁₉FN₈O

: 1239362-55-0
(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}pyrazolesulfonylurea

Guidance literature:: With ammonia; In methanol; at 20 ℃;

Reference yield:

: 1239363-34-8
(S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine

: 530-62-1
1,1'-carbonyldiimidazole

: 1239362-55-0
(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}pyrazolesulfonylurea

Guidance literature:: (S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine; 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃;

With ammonia; In methanol; dichloromethane; at 20 ℃;