L-3,5-dibromo-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-5'-t-butyl-N-trifluoroacetylthyronine methyl ester

Base Information

• Chemical Name: L-3,5-dibromo-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-5'-t-butyl-N-trifluoroacetylthyronine methyl ester
• CAS No.: 105190-17-8
• Molecular Formula: C₂₇H₂₆Br₂F₃N₃O₆
• Molecular Weight: 705.323
• Mol file: 105190-17-8.mol

Synonyms:L-3,5-dibromo-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-5'-t-butyl-N-trifluoroacetylthyronine methyl ester

Chemical Property of L-3,5-dibromo-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-5'-t-butyl-N-trifluoroacetylthyronine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-3,5-dibromo-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-5'-t-butyl-N-trifluoroacetylthyronine methyl ester

There total 5 articles about L-3,5-dibromo-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-5'-t-butyl-N-trifluoroacetylthyronine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

L-3,5-dibromo-3'-<(6-chloropyridazin-3-yl)methyl>-5'-t-butyl-N-trifluoroacetylthyronine methyl ester (105211-24-3) → L-3,5-dibromo-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-5'-t-butyl-N-trifluoroacetylthyronine methyl ester (105190-17-8)

Guidance literature:

With sodium acetate; In acetic acid; for 3h; Heating;

DOI:10.1039/P19880003097

Reference yield:

3-chloro-6-(2-methoxybenzyl)-pyridazine (105190-09-8) → L-3,5-dibromo-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-5'-t-butyl-N-trifluoroacetylthyronine methyl ester (105190-17-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / boron tribromide / CH₂Cl₂ / -50 deg C, RT, 30 min

2: 75percent sulphuric acid, urea / H₂O / 120 h / Ambient temperature

3: 1.) activated manganese dioxide, 2.) titanium tetrachloride / 1.) toluene, 0-8 deg C, 4 h, 2.) toluene, 5 min

4: 92 percent / sodium acetate / acetic acid / 3 h / Heating

With manganese(IV) oxide; sulfuric acid; sodium acetate; boron tribromide; titanium tetrachloride; urea; In dichloromethane; water; acetic acid;

DOI:10.1039/P19880003097

Reference yield:

2<6(-chloropyridazin-3-yl)methyl>phenol (105190-15-6) → L-3,5-dibromo-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-5'-t-butyl-N-trifluoroacetylthyronine methyl ester (105190-17-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 75percent sulphuric acid, urea / H₂O / 120 h / Ambient temperature

2: 1.) activated manganese dioxide, 2.) titanium tetrachloride / 1.) toluene, 0-8 deg C, 4 h, 2.) toluene, 5 min

3: 92 percent / sodium acetate / acetic acid / 3 h / Heating

With manganese(IV) oxide; sulfuric acid; sodium acetate; titanium tetrachloride; urea; In water; acetic acid;

DOI:10.1039/P19880003097

upstream raw materials:

L-3,5-dibromo-3'-<(6-chloropyridazin-3-yl)methyl>-5'-t-butyl-N-trifluoroacetylthyronine methyl ester

2<6(-chloropyridazin-3-yl)methyl>phenol

3-chloro-6-(2-methoxybenzyl)-pyridazine

2<(6-chloropyridazin-3-yl)methyl>4,6-di-t-butylphenol

Downstream raw materials:

SKF 94901

D-3,5-dibromo-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>thyronine