Technology Process of -6-<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-6-oxohexanoic acid monohydrochloride
There total 8 articles about -6-<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-6-oxohexanoic acid monohydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 84 percent / Et3N / tetrahydrofuran / 1 h / Ambient temperature
2: 99 percent / LiOH / dioxane; H2O / 24 h / Ambient temperature
3: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide, 2) Et3N / 1) ethyl acetate, rt, 2 h, 2) overnight
4: 98 percent / H2 / 20percent Pd/C / methanol / 4 h
5: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide / 1) ethyl acetate, 2 h, rt, 2) overnight
6: LiOH / dioxane; H2O / 3 h / Ambient temperature
7: 3 M HCl / ethyl acetate / 3 h / Ambient temperature
With
hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)86257-8
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide, 2) Et3N / 1) ethyl acetate, rt, 2 h, 2) overnight
2: 98 percent / H2 / 20percent Pd/C / methanol / 4 h
3: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide / 1) ethyl acetate, 2 h, rt, 2) overnight
4: LiOH / dioxane; H2O / 3 h / Ambient temperature
5: 3 M HCl / ethyl acetate / 3 h / Ambient temperature
With
hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)86257-8
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / LiOH / dioxane; H2O / 24 h / Ambient temperature
2: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide, 2) Et3N / 1) ethyl acetate, rt, 2 h, 2) overnight
3: 98 percent / H2 / 20percent Pd/C / methanol / 4 h
4: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide / 1) ethyl acetate, 2 h, rt, 2) overnight
5: LiOH / dioxane; H2O / 3 h / Ambient temperature
6: 3 M HCl / ethyl acetate / 3 h / Ambient temperature
With
hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)86257-8
