3-(5-mercapto-1,3,4-oxadiazole-2-yl)-1,5-diphenyl-1H-pyrazole-4-carbonitrile

Base Information

• Chemical Name: 3-(5-mercapto-1,3,4-oxadiazole-2-yl)-1,5-diphenyl-1H-pyrazole-4-carbonitrile
• CAS No.: 1244034-91-0
• Molecular Formula: C₁₈H₁₁N₅OS
• Molecular Weight: 345.384

Synonyms:3-(5-mercapto-1,3,4-oxadiazole-2-yl)-1,5-diphenyl-1H-pyrazole-4-carbonitrile

Chemical Property of 3-(5-mercapto-1,3,4-oxadiazole-2-yl)-1,5-diphenyl-1H-pyrazole-4-carbonitrile

Chemical Property:

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Technology Process of 3-(5-mercapto-1,3,4-oxadiazole-2-yl)-1,5-diphenyl-1H-pyrazole-4-carbonitrile

There total 4 articles about 3-(5-mercapto-1,3,4-oxadiazole-2-yl)-1,5-diphenyl-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C18H12N5OS2(1-)*K(1+) (1244034-90-9) → 3-(5-mercapto-1,3,4-oxadiazole-2-yl)-1,5-diphenyl-1H-pyrazole-4-carbonitrile (1244034-91-0)

Guidance literature:

With potassium hydroxide; In ethanol; for 4h; Reflux;

DOI:10.1002/ardp.200900176

Reference yield: 89.0%

carbon disulfide (75-15-0,12122-00-8) + 4-cyano-1,5-diphenyl-1H-pyrazole-3-carboxylic acid hydrazide (1244034-82-9) → 3-(5-mercapto-1,3,4-oxadiazole-2-yl)-1,5-diphenyl-1H-pyrazole-4-carbonitrile (1244034-91-0)

Guidance literature:

With potassium hydroxide; In ethanol; for 5h; Reflux;

DOI:10.1002/ardp.200900176

Reference yield:

4-cyano-1,5-diphenyl-1H-pyrazole-3-carboxylic acid ethyl ester (63514-89-6) → 3-(5-mercapto-1,3,4-oxadiazole-2-yl)-1,5-diphenyl-1H-pyrazole-4-carbonitrile (1244034-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 10 h / 20 °C

2: potassium hydroxide / ethanol / 5 h / Reflux

With potassium hydroxide; In ethanol;

DOI:10.1002/ardp.200900176

upstream raw materials:

carbon disulfide

4-cyano-1,5-diphenyl-1H-pyrazole-3-carboxylic acid hydrazide

C₁₈H₁₂N₅OS₂^(1-)*K⁽¹⁺⁾

4-cyano-1,5-diphenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Downstream raw materials:

3-(5-mercapto-4-amino-4H-1,2,4-triazol-3-yl)-1,5-diphenyl-1H-pyrazole-4-carbonitrile

6-phenyl-3-(4-cyano-1,5-diphenyl-1H-pyrazole-3-yl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole

6-benzyl-3-(4-cyano-1,5-diphenyl-1H-pyrazole-3-yl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole

3-(4-cyano-1,5-diphenyl-1H-pyrazole-3-yl)-6-phenyl-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine

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