(R)-2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl 4-methylbenzene-sulfonate

Base Information

• Chemical Name: (R)-2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl 4-methylbenzene-sulfonate
• CAS No.: 1399853-66-7
• Molecular Formula: C₁₉H₂₄O₆S
• Molecular Weight: 380.462

Synonyms:(R)-2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl 4-methylbenzene-sulfonate

Chemical Property of (R)-2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl 4-methylbenzene-sulfonate

Chemical Property:

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Technology Process of (R)-2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl 4-methylbenzene-sulfonate

There total 4 articles about (R)-2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl 4-methylbenzene-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

p-toluenesulfonyl chloride (98-59-9) + (2R)-4-(4-methoxyphenoxy)-2-methylbutane-1,2-diol (169310-89-8) → (R)-2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl 4-methylbenzene-sulfonate (1399853-66-7)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In chloroform; for 3h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.07.092

Reference yield:

4-methoxy-phenol (150-76-5) → (R)-2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl 4-methylbenzene-sulfonate (1399853-66-7)

Guidance literature:

Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine

2: AD-mix β / water; tert-butyl alcohol / 24 h / 4 °C

3: dmap; N-ethyl-N,N-diisopropylamine / chloroform / 3 h / Reflux; Inert atmosphere

With dmap; di-isopropyl azodicarboxylate; AD-mix β; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In chloroform; water; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2012.07.092

Reference yield:

2-methyl-1-buten-4-ol (763-32-6) → (R)-2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl 4-methylbenzene-sulfonate (1399853-66-7)

Guidance literature:

Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine

2: AD-mix β / water; tert-butyl alcohol / 24 h / 4 °C

3: dmap; N-ethyl-N,N-diisopropylamine / chloroform / 3 h / Reflux; Inert atmosphere

With dmap; di-isopropyl azodicarboxylate; AD-mix β; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In chloroform; water; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2012.07.092

upstream raw materials:

p-toluenesulfonyl chloride

(2R)-4-(4-methoxyphenoxy)-2-methylbutane-1,2-diol

2-methyl-1-buten-4-ol

4-methoxy-phenol

Downstream raw materials:

(R)-2-(2-methyloxiran-2-yl)ethyl 4-methylbenzenesulfonate

C₁₇H₂₅BrO₅S

(R)-2,4-dihydroxy-2-methylbutyl 4-methylbenzenesulfonate

(R)-2-hydroxy-2-methylbutan-1,4-yl bis(p-toluenesulfonate)

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