5-[8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctane-1-sulfonyl]-1-phenyl-1H-tetrazole

Base Information

• Chemical Name: 5-[8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctane-1-sulfonyl]-1-phenyl-1H-tetrazole
• CAS No.: 887278-76-4
• Molecular Formula: C₃₃H₄₄N₄O₃SSi
• Molecular Weight: 604.889
• Mol file: 887278-76-4.mol

Synonyms:5-[8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctane-1-sulfonyl]-1-phenyl-1H-tetrazole

Chemical Property of 5-[8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctane-1-sulfonyl]-1-phenyl-1H-tetrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctane-1-sulfonyl]-1-phenyl-1H-tetrazole

There total 14 articles about 5-[8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctane-1-sulfonyl]-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-[8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctylsulfanyl]-1-phenyl-1H-tetrazole (887278-75-3) → 5-[8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctane-1-sulfonyl]-1-phenyl-1H-tetrazole (887278-76-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/c3ob27277j

Reference yield:

8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctan-ol (200121-99-9) → 5-[8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctane-1-sulfonyl]-1-phenyl-1H-tetrazole (887278-76-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / PPh₃; DIAD / tetrahydrofuran / 0 - 20 °C

2: 95 percent / mCPBA / CH₂Cl₂ / 20 °C

With di-isopropyl azodicarboxylate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja060499i

Reference yield:

8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctanoic acid methyl ester (200122-06-1) → 5-[8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctane-1-sulfonyl]-1-phenyl-1H-tetrazole (887278-76-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / Dibal-H / tetrahydrofuran; toluene / 2 h / -78 °C

2: 91 percent / PPh₃; DIAD / tetrahydrofuran / 0 - 20 °C

3: 95 percent / mCPBA / CH₂Cl₂ / 20 °C

With di-isopropyl azodicarboxylate; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/ja060499i

upstream raw materials:

5-[8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctylsulfanyl]-1-phenyl-1H-tetrazole

tert-butylchlorodiphenylsilane

methyl 8-hydroxy-(3R,7S)-3,7-dimethyloctanoic acid

8-(tert-butyldiphenylsilanyloxy)-(3R,7S)-3,7-dimethyloctan-ol

Downstream raw materials:

tert-butyldiphenyl-(2S,6R,10S,14S)-2,6,10,14-tetramethylhenicos-8-enyloxysilane