(-)-tert-butyl (2S,3S)-3-benzylamino-3-(1-tert-butoxycarbonylindol-3-yl)-2-(3-hydroxypropyl)propanoate

Base Information

Chemical Name:(-)-tert-butyl (2S,3S)-3-benzylamino-3-(1-tert-butoxycarbonylindol-3-yl)-2-(3-hydroxypropyl)propanoate
CAS No.:1427722-30-2
Molecular Formula:C₃₀H₄₀N₂O₅
Molecular Weight:508.658
Hs Code.:

Synonyms:(-)-tert-butyl (2S,3S)-3-benzylamino-3-(1-tert-butoxycarbonylindol-3-yl)-2-(3-hydroxypropyl)propanoate

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Chemical Property of (-)-tert-butyl (2S,3S)-3-benzylamino-3-(1-tert-butoxycarbonylindol-3-yl)-2-(3-hydroxypropyl)propanoate

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Technology Process of (-)-tert-butyl (2S,3S)-3-benzylamino-3-(1-tert-butoxycarbonylindol-3-yl)-2-(3-hydroxypropyl)propanoate

There total 2 articles about (-)-tert-butyl (2S,3S)-3-benzylamino-3-(1-tert-butoxycarbonylindol-3-yl)-2-(3-hydroxypropyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14856-79-2
N-benzyl(trimethylsilyl)amine

: 862499-33-0
tert-butyl 3-(N-Boc-indol-3-yl)propenoate

: 78878-05-4
1-iodo-3-(tert-butyldimethylsilyloxy)propane

: (-)-tert-butyl (2R,3S)-3-benzylamino-3-(1-(tert-butoxycarbonyl)indol-3-yl)-2-(3-hydroxyprop-1-yl)propanoate

: 1427722-30-2
(-)-tert-butyl (2S,3S)-3-benzylamino-3-(1-tert-butoxycarbonylindol-3-yl)-2-(3-hydroxypropyl)propanoate

: 860003-60-7
3-(1H-indol-3-yl)acrylic acid tert-butyl ester

: C₁₈H₂₃NO₃

: (-)-tert-butyl 3-benzylamino-3-(1-[(tert-butoxy)carbonyl]indol-3-yl)-2-(3-hydroxypropyl)propanoate

Guidance literature:: N-benzyl(trimethylsilyl)amine; With n-butyllithium; In hexane; toluene; at -78 ℃; for 0.55h;

With (1S,2S)-1,2-dimethoxy-1,2-diphenylethane; In hexane; toluene; at -78 ℃; for 0.616667h;

tert-butyl 3-(N-Boc-indol-3-yl)propenoate; 1-iodo-3-(tert-butyldimethylsilyloxy)propane; Further stages;
DOI:10.1016/j.tet.2013.02.035

Reference yield:

: 14856-79-2
N-benzyl(trimethylsilyl)amine

: 862499-33-0
tert-butyl 3-(N-Boc-indol-3-yl)propenoate

: 78878-05-4
1-iodo-3-(tert-butyldimethylsilyloxy)propane

: (-)-tert-butyl (2R,3S)-3-benzylamino-3-(1-(tert-butoxycarbonyl)indol-3-yl)-2-(3-hydroxyprop-1-yl)propanoate

: 1427722-30-2
(-)-tert-butyl (2S,3S)-3-benzylamino-3-(1-tert-butoxycarbonylindol-3-yl)-2-(3-hydroxypropyl)propanoate

: C₁₈H₂₃NO₃

Guidance literature:: N-benzyl(trimethylsilyl)amine; With n-butyllithium; In hexane; toluene; at -78 ℃; for 0.55h;

tert-butyl 3-(N-Boc-indol-3-yl)propenoate; With (1S,2S)-1,2-dimethoxy-1,2-diphenylethane; In hexane; toluene; at -78 - -40 ℃; for 4h;

1-iodo-3-(tert-butyldimethylsilyloxy)propane; Further stages;
DOI:10.1016/j.tet.2013.02.035