2-(3,4-dimethoxybenzyl)-1H-benzimidazole

Base Information

• Chemical Name: 2-(3,4-dimethoxybenzyl)-1H-benzimidazole
• CAS No.: 59077-64-4
• Molecular Formula: C₁₆H₁₆N₂O₂
• Molecular Weight: 268.315
• Mol file: 59077-64-4.mol

Synonyms:2-(3,4-dimethoxybenzyl)-1H-benzo[d]imidazole

Chemical Property of 2-(3,4-dimethoxybenzyl)-1H-benzimidazole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-(3,4-DIMETHOXYBENZYL)-1H-BENZIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-dimethoxybenzyl)-1H-benzimidazole

There total 3 articles about 2-(3,4-dimethoxybenzyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) + 1,2-diamino-benzene (95-54-5) → 2-(3,4-dimethoxybenzyl)-1H-benzo[d]imidazole (59077-64-4)

Guidance literature:

With boric acid; In 5,5-dimethyl-1,3-cyclohexadiene; for 16h; Reflux;

DOI:10.1016/j.bmc.2016.03.012

Reference yield: 66.0%

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + 1,2-diamino-benzene (95-54-5) → 2-(3,4-dimethoxybenzyl)-1H-benzo[d]imidazole (59077-64-4)

Guidance literature:

With but-2-enenitrile; 10% Pd/C; acetic acid; In water; toluene; at 170 ℃; for 1.5h; under 15514.9 Torr; Microwave irradiation; Inert atmosphere;

DOI:10.1002/adsc.201200253 DOI:10.1002/adsc.201200253

Reference yield:

→ 2-(3,4-dimethoxybenzyl)-1H-benzo[d]imidazole (59077-64-4)

Guidance literature:

3.4-Dimethoxy-benzylcyanid mit Aethanol u. HCl, dann o-Phenylendiamin;

DOI:10.1002/hlca.19600430323

upstream raw materials:

(3,4-Dimethoxyphenyl)acetic acid

1,2-diamino-benzene

2-(3,4-dimethoxyphenyl)-ethylamine

Downstream raw materials:

1-(but-3-en-1-yl)-2-(3,4-dimethoxybenzyl)-1H-benzo[d]imidazole

2-(3,4-dimethoxybenzyl)-1-ethyl-1H-benzo[d]imidazole

ethyl 2-(3,4-dimethoxybenzyl)-1H-benzo[d]imidazole-1-carboxylate

(1-(but-3-en-1-yl)-1H-benzo[d]imidazol-2-yl)(3,4-dimethoxyphenyl)methanone

Refernces

• 1、 Dos Santos, Aurelie,El Kaim, Laurent,Grimaud, Laurence. "Metal-free aerobic oxidation of benzazole derivatives". supporting information. p. 3282 - 3287. Retrieved 2013/06/05.
• 2、 Pizzetti, Marianna,De Luca, Elisa,Petricci, Elena,Porcheddu, Andrea,Taddei, Maurizio. "A general approach to substituted benzimidazoles and benzoxazoles via heterogeneous palladium-catalyzed hydrogen-transfer with primary amines". . p. 2453 - 2464. Retrieved 2013/01/14.