(4S,R(S))-ethyl N-(tert-butylsulfinyl)-4-amino-2-methylene-4-phenylbutanoate

Base Information

• Chemical Name: (4S,R(S))-ethyl N-(tert-butylsulfinyl)-4-amino-2-methylene-4-phenylbutanoate
• CAS No.: 1211540-56-5
• Molecular Formula: C₁₇H₂₅NO₃S
• Molecular Weight: 323.456
• Mol file: 1211540-56-5.mol

Synonyms:(4S,R(S))-ethyl N-(tert-butylsulfinyl)-4-amino-2-methylene-4-phenylbutanoate

Chemical Property of (4S,R(S))-ethyl N-(tert-butylsulfinyl)-4-amino-2-methylene-4-phenylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,R(S))-ethyl N-(tert-butylsulfinyl)-4-amino-2-methylene-4-phenylbutanoate

There total 1 articles about (4S,R(S))-ethyl N-(tert-butylsulfinyl)-4-amino-2-methylene-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(R)-N-benzylidene-2-methylpropane-2-sulfinamide (196929-85-8) + ethyl 2-bromomethyl-2-propenoate (17435-72-2) → (4S,R(S))-ethyl N-(tert-butylsulfinyl)-4-amino-2-methylene-4-phenylbutanoate (1211540-56-5) + (4R,R(S))-ethyl N-(tert-butylsulfinyl)-4-amino-2-methylene-4-phenylbutanoate (1211540-51-0)

Guidance literature:

With indium; sodium bromide; In water; at 23 ℃; for 48h; optical yield given as %de; diastereoselective reaction;

DOI:10.3987/COM-10-S(E)94

Reference yield: 93.0%

(4S,R(S))-ethyl N-(tert-butylsulfinyl)-4-amino-2-methylene-4-phenylbutanoate (1211540-56-5) → (S)-3-methylene-5-phenyl-2-pyrrolidinone (125216-88-8)

Guidance literature:

(4S,R(S))-ethyl N-(tert-butylsulfinyl)-4-amino-2-methylene-4-phenylbutanoate; With hydrogenchloride; In 1,4-dioxane; methanol; at 0 ℃; for 2h;

With sodium methylate; In methanol; at 0 ℃; for 1h;

DOI:10.3987/COM-10-S(E)94

upstream raw materials:

(R)-N-benzylidene-2-methylpropane-2-sulfinamide

ethyl 2-bromomethyl-2-propenoate

Downstream raw materials:

(S)-3-methylene-5-phenyl-2-pyrrolidinone