methyl (7S)-6-N-[(2′S,4′R)-4′-(n-butyl)piperidine-2′-carbonyl]-7-deoxy-7-[5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl-thio]-α-thiolincosaminide

Base Information

Chemical Name:methyl (7S)-6-N-[(2′S,4′R)-4′-(n-butyl)piperidine-2′-carbonyl]-7-deoxy-7-[5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl-thio]-α-thiolincosaminide
CAS No.:941587-51-5
Molecular Formula:C₂₇H₃₉N₅O₇S₃
Molecular Weight:641.834
Hs Code.:

Synonyms:methyl (7S)-6-N-[(2′S,4′R)-4′-(n-butyl)piperidine-2′-carbonyl]-7-deoxy-7-[5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl-thio]-α-thiolincosaminide

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Chemical Property of methyl (7S)-6-N-[(2′S,4′R)-4′-(n-butyl)piperidine-2′-carbonyl]-7-deoxy-7-[5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl-thio]-α-thiolincosaminide

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Technology Process of methyl (7S)-6-N-[(2′S,4′R)-4′-(n-butyl)piperidine-2′-carbonyl]-7-deoxy-7-[5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl-thio]-α-thiolincosaminide

There total 5 articles about methyl (7S)-6-N-[(2′S,4′R)-4′-(n-butyl)piperidine-2′-carbonyl]-7-deoxy-7-[5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl-thio]-α-thiolincosaminide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 941587-51-5
methyl (7S)-6-N-[(2′S,4′R)-4′-(n-butyl)piperidine-2′-carbonyl]-7-deoxy-7-[5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl-thio]-α-thiolincosaminide

Guidance literature:

Reference yield:

: C₄₁H₇₁N₅O₉S₃Si₃

: 941587-51-5
methyl (7S)-6-N-[(2′S,4′R)-4′-(n-butyl)piperidine-2′-carbonyl]-7-deoxy-7-[5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl-thio]-α-thiolincosaminide

Guidance literature:: C₄₁H₇₁N₅O₉S₃Si₃; With hydrogenchloride; In methanol; water; at 20 ℃; for 1h;

With trifluoroacetic acid; In dichloromethane; at -20 - 20 ℃; for 0.5h;
DOI:10.1038/ja.2017.143

Reference yield:

: C₃₆H₇₆N₂O₈SSi₄

: 941587-51-5
methyl (7S)-6-N-[(2′S,4′R)-4′-(n-butyl)piperidine-2′-carbonyl]-7-deoxy-7-[5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl-thio]-α-thiolincosaminide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / methanol / 0.67 h / 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C

2.2: 3 h / 20 °C

3.1: hydrogenchloride / methanol; water / 1 h / 20 °C

3.2: 0.5 h / -20 - 20 °C

With hydrogenchloride; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; 2.1: |Mitsunobu Displacement;
DOI:10.1038/ja.2017.143