2-(4-((1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)ethynyl)phenyl)-N-phenylacetamide

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Chemical Name:2-(4-((1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)ethynyl)phenyl)-N-phenylacetamide
CAS No.:1361574-43-7
Molecular Formula:C₂₂H₁₇NO₃
Molecular Weight:343.382
Hs Code.:

Synonyms:2-(4-((1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)ethynyl)phenyl)-N-phenylacetamide

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Chemical Property of 2-(4-((1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)ethynyl)phenyl)-N-phenylacetamide

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Technology Process of 2-(4-((1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)ethynyl)phenyl)-N-phenylacetamide

There total 4 articles about 2-(4-((1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)ethynyl)phenyl)-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1361574-70-0
2-(4-((1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)ethynyl)phenyl)acetic acid

: 62-53-3
aniline

: 1361574-43-7
2-(4-((1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)ethynyl)phenyl)-N-phenylacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.12.018

Reference yield:

: 150-76-5
4-methoxy-phenol

: 1361574-43-7
2-(4-((1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)ethynyl)phenyl)-N-phenylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: [bis(acetoxy)iodo]benzene / 1.66 h / Inert atmosphere

2.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.2: Saturated solution

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine / N,N-dimethyl acetamide; water / 0.17 h / 100 °C / Microwave irradiation

4.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 25 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; [bis(acetoxy)iodo]benzene; diisopropylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.018

Reference yield:

: 935-50-2
4,4-dimethoxycyclohexa-2,5-dienone

: 1361574-43-7
2-(4-((1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)ethynyl)phenyl)-N-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

1.2: Saturated solution

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine / N,N-dimethyl acetamide; water / 0.17 h / 100 °C / Microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 25 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.018