N2-Phenyl-N7-(3,4,5-trimethoxybenzyl)thiazolo[5,4-d]pyrimidine-2,7-diamine

Base Information

Chemical Name:N2-Phenyl-N7-(3,4,5-trimethoxybenzyl)thiazolo[5,4-d]pyrimidine-2,7-diamine
CAS No.:871266-77-2
Molecular Formula:C₂₁H₂₁N₅O₃S
Molecular Weight:423.495
Hs Code.:
DSSTox Substance ID:DTXSID90470339
Wikidata:Q82298408
Mol file:871266-77-2.mol

Synonyms:871266-77-2;N2-Phenyl-N7-(3,4,5-trimethoxybenzyl)thiazolo[5,4-d]pyrimidine-2,7-diamine;2-N-phenyl-7-N-[(3,4,5-trimethoxyphenyl)methyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine;DTXSID90470339;N~2~-Phenyl-N~7~-[(3,4,5-trimethoxyphenyl)methyl][1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine

Suppliers and Price of N2-Phenyl-N7-(3,4,5-trimethoxybenzyl)thiazolo[5,4-d]pyrimidine-2,7-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N2-Phenyl-N7-(3,4,5-trimethoxybenzyl)thiazolo[5,4-d]pyrimidine-2,7-diamine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.701
Boiling Point:605.55°C at 760 mmHg
Flash Point:320.026°C
PSA：118.66000
Density:1.362g/cm³
LogP:4.61380
XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:423.13651072
Heavy Atom Count:30
Complexity:513

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)CNC2=C3C(=NC=N2)SC(=N3)NC4=CC=CC=C4

Technology Process of N2-Phenyl-N7-(3,4,5-trimethoxybenzyl)thiazolo[5,4-d]pyrimidine-2,7-diamine

There total 4 articles about N2-Phenyl-N7-(3,4,5-trimethoxybenzyl)thiazolo[5,4-d]pyrimidine-2,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 871266-78-3
(7-chloro[1,3]thiazolo[5,4-d]pyrimidin-2-yl)(phenyl)amine

: 18638-99-8
3,4,5-trimethoxybenzylamine

: 871266-77-2
N²-phenyl-N⁷-(3,4,5-trimethoxybenzyl)[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine

Guidance literature:: With triethylamine; In tetrahydrofuran; for 16h; Heating;
DOI:10.1021/jo0517702

Reference yield: 20.0%

: 6-chloro-N⁴-(3,4,5-trimethoxybenzyl)pyrimidine-4,5-diamine

: 103-72-0
phenyl isothiocyanate

: 871266-77-2
N²-phenyl-N⁷-(3,4,5-trimethoxybenzyl)[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1021/jo0517702

Reference yield:

: 18638-99-8
3,4,5-trimethoxybenzylamine

: 871266-77-2
N²-phenyl-N⁷-(3,4,5-trimethoxybenzyl)[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / triethylamine / butan-1-ol / 16 h / 80 °C

2: 20 percent / DBU / dimethylformamide / 48 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/jo0517702