2,2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole

Base Information

Chemical Name:2,2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole
CAS No.:107124-31-2
Molecular Formula:C₁₄H₁₃Cl₂NO₄S
Molecular Weight:362.234
Hs Code.:

Synonyms:2,2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole

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Chemical Property of 2,2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole

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Technology Process of 2,2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole

There total 4 articles about 2,2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107124-27-6
dimethyl 2,2-dioxo-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate

: 107124-31-2
2,2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole

Guidance literature:: With aluminium hydride * diethyl ether; In tetrahydrofuran; at -12 ℃; for 1h;

Reference yield:

: 3024-72-4
3,4-dichlorobenzoyl chloride

: 107124-31-2
2,2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / aq. 15percent NaOH / H₂O; diethyl ether / 16 h / 25 °C

2: 68 percent / acetic anhydride / 6 h / 120 °C

3: 76 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

4: AlBH₃ / tetrahydrofuran / 5 h / 35 °C

With sodium hydroxide; acetic anhydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/jm00394a030

Reference yield:

: 110271-24-4
N-(3,4-dichlorobenzoyl)thiazolidine-4-carboxylic acid

: 107124-31-2
2,2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / acetic anhydride / 6 h / 120 °C

2: 76 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

3: AlBH₃ / tetrahydrofuran / 5 h / 35 °C

With acetic anhydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00394a030