3-methyl-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride

Base Information

• Chemical Name: 3-methyl-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride
• CAS No.: 870889-89-7
• Molecular Formula: C₈H₁₅NO*ClH
• Molecular Weight: 177.674
• Mol file: 870889-89-7.mol

Synonyms:endo-3-exo-methyl-8-azabicyclo[3.2.1]octan-3-ol hydrochloride

Chemical Property of 3-methyl-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-Methyl-3-hydroxy-8-azabicyclo[3.2.1]octanehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride

There total 1 articles about 3-methyl-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (870889-86-4) → endo-3-exo-methyl-8-azabicyclo[3.2.1]octan-3-ol hydrochloride (870889-89-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether; for 2h;

Reference yield: 40.0%

2-chloro-4-fluoro-3-methylbenzonitrile (796600-15-2) + endo-3-exo-methyl-8-azabicyclo[3.2.1]octan-3-ol hydrochloride (870889-89-7) → ACP-105 (899821-23-9)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 18h;

Reference yield:

2-chloro-4-fluoro-3-methylbenzonitrile (796600-15-2) + endo-3-exo-methyl-8-azabicyclo[3.2.1]octan-3-ol hydrochloride (870889-89-7) → 2-chloro-4-(3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]-oct-8-yl)-3-methylbenzonitrile hydrochloride

Guidance literature:

2-chloro-4-fluoro-3-methylbenzonitrile; endo-3-exo-methyl-8-azabicyclo[3.2.1]octan-3-ol hydrochloride; With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 18h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; water; for 0.25h;

DOI:10.1021/jm901149c

upstream raw materials:

3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Downstream raw materials:

ACP-105

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