tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate

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Chemical Name:tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate
CAS No.:737827-46-2
Molecular Formula:C₃₃H₄₃N₅O₇S₂
Molecular Weight:685.866
Hs Code.:

tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate

Synonyms:tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate

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Chemical Property of tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate

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Technology Process of tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate

There total 15 articles about tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 737827-45-1
N-(4-[2-(4-aminophenyl)ethyl]-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-2-yl)acetamide

: 152120-54-2,862686-58-6,1143572-00-2
N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine

: 737827-46-2
tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 737823-53-9
ethyl 2-(acetylamino)-4-[(E)-2-(4-nitrophenyl)ethenyl]-1,3-thiazole-5-carboxylate

: 737827-46-2
tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 3 h / 20 °C / 3040.2 Torr / Inert atmosphere

2.1: tetrahydrofuran / 2 h / Inert atmosphere; Reflux

3.1: sodium hydroxide / ethanol / 5 h / Reflux

3.2: 20 °C / pH 4

4.1: pyridine / 0 - 20 °C / Inert atmosphere

5.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide; dichloromethane / 3 h / 20 °C / Inert atmosphere

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

7.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 20 °C / 2280.15 Torr

9.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 20 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 7.1: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 62591-33-7
ethyl 2-(acetylamino)-4-(chloromethyl)-1,3-thiazole-5-carboxylate

: 737827-46-2
tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate

Guidance literature:: Multi-step reaction with 12 steps

1.1: N,N-dimethyl-formamide / 5 h / 65 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 3 h / 20 °C / 3040.2 Torr / Inert atmosphere

4.1: tetrahydrofuran / 2 h / Inert atmosphere; Reflux

5.1: sodium hydroxide / ethanol / 5 h / Reflux

5.2: 20 °C / pH 4

6.1: pyridine / 0 - 20 °C / Inert atmosphere

7.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide; dichloromethane / 3 h / 20 °C / Inert atmosphere

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

9.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

10.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 20 °C / 2280.15 Torr

11.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C / Inert atmosphere

12.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 20 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 2.2: |Wittig Olefination / 9.1: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.02.048