N-nosyl-1²,2⁴-dimethoxy-5-aza-1(1,4),2(1,2)-dibenzenacycloheptaphane

Base Information

Chemical Name:N-nosyl-1²,2⁴-dimethoxy-5-aza-1(1,4),2(1,2)-dibenzenacycloheptaphane
CAS No.:888030-04-4
Molecular Formula:C₂₄H₂₄N₂O₆S
Molecular Weight:468.53
Hs Code.:

N-nosyl-1<sup>2</sup>,2<sup>4</sup>-dimethoxy-5-aza-1(1,4),2(1,2)-dibenzenacycloheptaphane

Synonyms:N-nosyl-1²,2⁴-dimethoxy-5-aza-1(1,4),2(1,2)-dibenzenacycloheptaphane

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Chemical Property of N-nosyl-1²,2⁴-dimethoxy-5-aza-1(1,4),2(1,2)-dibenzenacycloheptaphane

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Technology Process of N-nosyl-1²,2⁴-dimethoxy-5-aza-1(1,4),2(1,2)-dibenzenacycloheptaphane

There total 12 articles about N-nosyl-1²,2⁴-dimethoxy-5-aza-1(1,4),2(1,2)-dibenzenacycloheptaphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 888030-06-6
2-(2-iodo-5-methoxyphenyl)acetamide

: 888030-04-4
N-nosyl-1²,2⁴-dimethoxy-5-aza-1(1,4),2(1,2)-dibenzenacycloheptaphane

Guidance literature:: Multi-step reaction with 10 steps

1.1: BH₃*THF / tetrahydrofuran / 3 h / Heating

1.2: 5.93 g / triethylamine / CH₂Cl₂ / 19 h / 20 °C

2.1: 98 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 20 °C

3.1: DPEphos; triethylamine; pinacolborane / Pd(OAc)2 / CH₂Cl₂ / 1 h / 85 °C

3.2: Cs₂CO₃ / Pd(PPh₃)4 / dimethylsulfoxide / 2 h / 81 °C

3.3: 946 mg / TBAF / tetrahydrofuran / 3 h / 20 °C

4.1: 90 percent / 0.33 h / 165 °C

5.1: 57 percent / triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran / 12 h / 20 °C

6.1: 97 percent / m-CPBA / CH₂Cl₂ / 17 h / 20 °C

7.1: 393 mg / tetrafluoroboric acid / CHCl₃ / 22 h / 20 °C

8.1: 253 mg / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

9.1: 2,2,2-trifluoroethanol; DIPEA / 1 h / 170 °C

10.1: 25.9 mg / potassium carbonate / acetone / 7 h / Heating

With dmap; tetrafluoroboric acid; borane-THF; Pinacolborane; 2,2,2-trifluoroethanol; potassium carbonate; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; bis[2-(diphenylphosphino)phenyl] ether; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; dichloromethane; chloroform; acetone; toluene; 3.2: Suzuki-Miyaura reaction / 5.1: Mitsunobu reaction;
DOI:10.1021/ol060455e

Reference yield:

: 888030-07-7
N-nosyl-2-(2-iodo-5-methoxyphenyl)ethanamine

: 888030-04-4
N-nosyl-1²,2⁴-dimethoxy-5-aza-1(1,4),2(1,2)-dibenzenacycloheptaphane

Guidance literature:: Multi-step reaction with 9 steps

1.1: 98 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 20 °C

2.1: DPEphos; triethylamine; pinacolborane / Pd(OAc)2 / CH₂Cl₂ / 1 h / 85 °C

2.2: Cs₂CO₃ / Pd(PPh₃)4 / dimethylsulfoxide / 2 h / 81 °C

2.3: 946 mg / TBAF / tetrahydrofuran / 3 h / 20 °C

3.1: 90 percent / 0.33 h / 165 °C

4.1: 57 percent / triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran / 12 h / 20 °C

5.1: 97 percent / m-CPBA / CH₂Cl₂ / 17 h / 20 °C

6.1: 393 mg / tetrafluoroboric acid / CHCl₃ / 22 h / 20 °C

7.1: 253 mg / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

8.1: 2,2,2-trifluoroethanol; DIPEA / 1 h / 170 °C

9.1: 25.9 mg / potassium carbonate / acetone / 7 h / Heating

With dmap; tetrafluoroboric acid; Pinacolborane; 2,2,2-trifluoroethanol; potassium carbonate; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; bis[2-(diphenylphosphino)phenyl] ether; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; dichloromethane; chloroform; acetone; toluene; 2.2: Suzuki-Miyaura reaction / 4.1: Mitsunobu reaction;
DOI:10.1021/ol060455e

Reference yield:

: 888029-96-7
N-Boc-N-nosyl-2-(2-iodo-5-methoxyphenyl)ethanamine

: 888030-04-4
N-nosyl-1²,2⁴-dimethoxy-5-aza-1(1,4),2(1,2)-dibenzenacycloheptaphane

Guidance literature:: Multi-step reaction with 8 steps

1.1: DPEphos; triethylamine; pinacolborane / Pd(OAc)2 / CH₂Cl₂ / 1 h / 85 °C

1.2: Cs₂CO₃ / Pd(PPh₃)4 / dimethylsulfoxide / 2 h / 81 °C

1.3: 946 mg / TBAF / tetrahydrofuran / 3 h / 20 °C

2.1: 90 percent / 0.33 h / 165 °C

3.1: 57 percent / triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran / 12 h / 20 °C

4.1: 97 percent / m-CPBA / CH₂Cl₂ / 17 h / 20 °C

5.1: 393 mg / tetrafluoroboric acid / CHCl₃ / 22 h / 20 °C

6.1: 253 mg / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

7.1: 2,2,2-trifluoroethanol; DIPEA / 1 h / 170 °C

8.1: 25.9 mg / potassium carbonate / acetone / 7 h / Heating

With tetrafluoroboric acid; Pinacolborane; 2,2,2-trifluoroethanol; potassium carbonate; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; bis[2-(diphenylphosphino)phenyl] ether; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; dichloromethane; chloroform; acetone; toluene; 1.2: Suzuki-Miyaura reaction / 3.1: Mitsunobu reaction;
DOI:10.1021/ol060455e