6-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Base Information

Chemical Name:6-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyrimidin-4-amine
CAS No.:1603922-85-5
Molecular Formula:C₁₈H₁₇FN₄O₃S
Molecular Weight:388.422
Hs Code.:

Synonyms:6-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyrimidin-4-amine

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Chemical Property of 6-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyrimidin-4-amine

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Technology Process of 6-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyrimidin-4-amine

There total 5 articles about 6-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1603922-96-8
6-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfanyl)methyl]pyridin-2-yl}pyrimidin-4-amine

: 1603922-85-5
6-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Guidance literature:: With potassium permanganate; In acetone; at 40 ℃; for 1h;

Reference yield:

: 179899-07-1
4-fluoro-2-methoxyphenylboronic acid

: 1603922-85-5
6-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,2-dimethoxyethane / 2.5 h / 90 °C / Inert atmosphere

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

3: potassium permanganate / acetone / 1 h / 40 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium permanganate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1,2-dimethoxyethane; acetone;

Reference yield:

: 954221-72-8
4-chloro-6-(4-fluoro-2-methoxy-phenyl)-pyrimidine

: 1603922-85-5
6-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

2: potassium permanganate / acetone / 1 h / 40 °C

With potassium permanganate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; acetone;