N-(4-bromo-2-{5-chloro-2-[4-(4-methylpiperazin-1-yl)-3-vinylphenylamino]pyrimidin-4-ylamino}phenyl)-N-methylmethanesulfonamide

Base Information

Chemical Name:N-(4-bromo-2-{5-chloro-2-[4-(4-methylpiperazin-1-yl)-3-vinylphenylamino]pyrimidin-4-ylamino}phenyl)-N-methylmethanesulfonamide
CAS No.:1352244-34-8
Molecular Formula:C₂₅H₂₉BrClN₇O₂S
Molecular Weight:606.974
Hs Code.:

Synonyms:N-(4-bromo-2-{5-chloro-2-[4-(4-methylpiperazin-1-yl)-3-vinylphenylamino]pyrimidin-4-ylamino}phenyl)-N-methylmethanesulfonamide

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Chemical Property of N-(4-bromo-2-{5-chloro-2-[4-(4-methylpiperazin-1-yl)-3-vinylphenylamino]pyrimidin-4-ylamino}phenyl)-N-methylmethanesulfonamide

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Technology Process of N-(4-bromo-2-{5-chloro-2-[4-(4-methylpiperazin-1-yl)-3-vinylphenylamino]pyrimidin-4-ylamino}phenyl)-N-methylmethanesulfonamide

There total 9 articles about N-(4-bromo-2-{5-chloro-2-[4-(4-methylpiperazin-1-yl)-3-vinylphenylamino]pyrimidin-4-ylamino}phenyl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1352244-23-5
4-(4-methylpiperazin-1-yl)-3-vinylphenylamine

: 1352244-20-2
N-[4-bromo-2-(2,5-dichloropyrimidin-4-ylamino)phenyl]-N-methylmethanesulfonamide

: 1352244-34-8
N-(4-bromo-2-{5-chloro-2-[4-(4-methylpiperazin-1-yl)-3-vinylphenylamino]pyrimidin-4-ylamino}phenyl)-N-methylmethanesulfonamide

Guidance literature:: With methanesulfonic acid; In ethyl methyl ether; at 110 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm201333e

Reference yield:

: 477846-54-1
1-(2-bromo-4-nitrobenzene)-4-methylpiperazine

: 1352244-34-8
N-(4-bromo-2-{5-chloro-2-[4-(4-methylpiperazin-1-yl)-3-vinylphenylamino]pyrimidin-4-ylamino}phenyl)-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 5 h / 90 °C / Inert atmosphere

2: iron; acetic acid / tetrahydrofuran / 16 h / 35 °C / Inert atmosphere

3: methanesulfonic acid / ethyl methyl ether / 4 h / 110 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; iron; potassium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; ethyl methyl ether; water;
DOI:10.1021/jm201333e

Reference yield:

: 1078136-96-5
N-(4-bromo-2-nitrophenyl)-N-methylmethanesulfonamide

: 1352244-34-8
N-(4-bromo-2-{5-chloro-2-[4-(4-methylpiperazin-1-yl)-3-vinylphenylamino]pyrimidin-4-ylamino}phenyl)-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: iron; acetic acid / tetrahydrofuran / 2 h / 35 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 48 h / 100 °C / Inert atmosphere

3: methanesulfonic acid / ethyl methyl ether / 4 h / 110 °C / Inert atmosphere

With methanesulfonic acid; iron; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethyl methyl ether;
DOI:10.1021/jm201333e