4-Oxo-pentanoic acid (2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester

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Chemical Name:4-Oxo-pentanoic acid (2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester
CAS No.:202864-96-8
Molecular Formula:C₄₀H₃₇Cl₂NO₁₀
Molecular Weight:762.64
Hs Code.:

4-Oxo-pentanoic acid (2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester

Synonyms:4-Oxo-pentanoic acid (2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester

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Chemical Property of 4-Oxo-pentanoic acid (2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester

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Technology Process of 4-Oxo-pentanoic acid (2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester

There total 10 articles about 4-Oxo-pentanoic acid (2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 40608-06-8
levulinic anhydride

: 202864-95-7
p-methoxyphenyl 3,6-di-O-benzyl-2-deoxy-2-(4,5-dichlorophthalimido)-β-D-glucopyranoside

: 202864-96-8
4-Oxo-pentanoic acid (2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester

Guidance literature:: With pyridine; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(97)10377-5

Reference yield:

: 942-06-3
4,5-dichlorophthalic anhydride

: 202864-96-8
4-Oxo-pentanoic acid (2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Et₃N, 2.) Ac₂O, pyridine / 1) 1,2-dichloroethane, 50-60 deg C, 2 h; 2) rt, 24 h

2: 87 percent / TMSOTf / 1,2-dichloro-ethane / 42 h

3: 25 g / NaOMe / methanol; CH₂Cl₂ / 4 h / 0 °C

4: 74 percent / camphorsulphonic acid / dimethylformamide / 60 h / Ambient temperature

5: 4 Angstroem molecular sieves, NaH / dimethylformamide / 28 h / 6 °C

6: 4 Angstroem molecular sieves, sodium cyanoborohydride, aq. HCl / tetrahydrofuran / 7 h / Ambient temperature

7: 95 percent / pyridine / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; camphor-10-sulfonic acid; sodium methylate; acetic anhydride; sodium hydride; sodium cyanoborohydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)10377-5

Reference yield:

: 5432-46-2,10034-19-2,10034-20-5,34948-62-4,110253-00-4,1191127-63-5
1,3,4,6-tetra-O-acetyl-D-glucosamine hydrochloride

: 202864-96-8
4-Oxo-pentanoic acid (2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Et₃N, 2.) Ac₂O, pyridine / 1) 1,2-dichloroethane, 50-60 deg C, 2 h; 2) rt, 24 h

2: 87 percent / TMSOTf / 1,2-dichloro-ethane / 42 h

3: 25 g / NaOMe / methanol; CH₂Cl₂ / 4 h / 0 °C

4: 74 percent / camphorsulphonic acid / dimethylformamide / 60 h / Ambient temperature

5: 4 Angstroem molecular sieves, NaH / dimethylformamide / 28 h / 6 °C

6: 4 Angstroem molecular sieves, sodium cyanoborohydride, aq. HCl / tetrahydrofuran / 7 h / Ambient temperature

7: 95 percent / pyridine / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; camphor-10-sulfonic acid; sodium methylate; acetic anhydride; sodium hydride; sodium cyanoborohydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)10377-5