4,5-Difluoro-2-methoxyphenylboronic acid

Base Information

Chemical Name:4,5-Difluoro-2-methoxyphenylboronic acid
CAS No.:870777-32-5
Molecular Formula:C7H7 B F2 O3
Molecular Weight:187.939
Hs Code.:2931900090
European Community (EC) Number:685-877-3
DSSTox Substance ID:DTXSID50584481
Wikidata:Q72463345
Mol file:870777-32-5.mol

Synonyms:870777-32-5;(4,5-Difluoro-2-methoxyphenyl)boronic acid;4,5-Difluoro-2-methoxyphenylboronic acid;MFCD08275291;(4,5-Difluoro-2-methoxy-phenyl)boronic acid;4,5-Difluoro-2-methoxybenzeneboronic acid;(4,5-Difluoro-2-methoxyphenyl)boronicacid;SCHEMBL1756413;DTXSID50584481;ISQCHQGYKNHYGP-UHFFFAOYSA-N;AKOS015853454;CS-W016835;DS-2540;AM808073;SY025871;4,5-difluoro-2-methoxy phenylboronic acid;4,5-Difluoro-2-methoxyphenyl-boronic acid;EN300-4290289;A862891;Boronic acid, B-(4,5-difluoro-2-methoxyphenyl)-

Suppliers and Price of 4,5-Difluoro-2-methoxyphenylboronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4,5-Difluoro-2-methoxyphenylboronic acid
1g
$ 75.00

SynQuest Laboratories
4,5-Difluoro-2-methoxybenzeneboronic acid
5 g
$ 167.00

SynQuest Laboratories
4,5-Difluoro-2-methoxybenzeneboronic acid
1 g
$ 45.00

Sigma-Aldrich
4,5-Difluoro-2-methoxyphenylboronic acid
5g
$ 484.00

Sigma-Aldrich
4,5-Difluoro-2-methoxyphenylboronic acid
1g
$ 142.00

Matrix Scientific
4,5-Difluoro-2-methoxyphenylboronic acid >95%
1g
$ 180.00

Matrix Scientific
4,5-Difluoro-2-methoxyphenylboronic acid >95%
5g
$ 630.00

Crysdot
4,5-Difluoro-2-methoxyphenylboronic acid 98%
10g
$ 203.00

Chemenu
4,5-Difluoro-2-methoxyphenylboronic acid 95+%
10g
$ 155.00

Chemenu
4,5-Difluoro-2-methoxyphenylboronic acid 95+%
5g
$ 87.00

Total 28 raw suppliers

Chemical Property of 4,5-Difluoro-2-methoxyphenylboronic acid

Chemical Property:

Vapor Pressure:0.000205mmHg at 25°C
Melting Point:175-180 °C(lit.)
Refractive Index:1.485
Boiling Point:313.9°C at 760 mmHg
PKA:7.61±0.58(Predicted)
Flash Point:143.7°C
PSA：49.69000
Density:1.35g/cm³
LogP:-0.34680
Storage Temp.:2-8°C
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:188.0456306
Heavy Atom Count:13
Complexity:170

Purity/Quality:

97% ^*data from raw suppliers

4,5-Difluoro-2-methoxyphenylboronic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:B(C1=CC(=C(C=C1OC)F)F)(O)O
Uses Contains varying amounts of anhydride

Technology Process of 4,5-Difluoro-2-methoxyphenylboronic acid

There total 1 articles about 4,5-Difluoro-2-methoxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 202865-58-5
1-bromo-4,5-difluoro-2-methoxybenzene

: 870777-32-5
(4,5-difluoro-2-methoxyphenyl)boronic acid

Guidance literature:: 1-bromo-4,5-difluoro-2-methoxybenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With triisopropyl borate;

With hydrogenchloride; In water; ethyl acetate;
DOI:10.1021/jm400287v

Reference yield: 96.0%

: 870777-32-5
(4,5-difluoro-2-methoxyphenyl)boronic acid

: 1152570-03-0
3-(4-iodo-phenoxymethyl)-benzonitrile

: 1310036-71-5
3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzonitrile

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; at 60 ℃; for 2h;

Reference yield: 88.0%

: 870777-32-5
(4,5-difluoro-2-methoxyphenyl)boronic acid

: (S)-4-(7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[ 2,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-carboxylic acid tert-butyl ester

: tert-butyl (S)-4-(7-(4,5-difluoro-2-methoxyphenyl)-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate

Guidance literature:: With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium acetate; In 1,4-dioxane; water; at 90 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.113082