gadolinium 2,2',2''-(10-{1-[(2-{[6-(4-ethynylphenyl)hexyl]amino}-2-oxoethyl)amino]-1-oxopropan-2-yl}-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Base Information

Chemical Name:gadolinium 2,2',2''-(10-{1-[(2-{[6-(4-ethynylphenyl)hexyl]amino}-2-oxoethyl)amino]-1-oxopropan-2-yl}-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
CAS No.:1621926-58-6
Molecular Formula:C₃₃H₄₇N₆O₈*Gd
Molecular Weight:813.022
Hs Code.:

gadolinium 2,2',2''-(10-{1-[(2-{[6-(4-ethynylphenyl)hexyl]amino}-2-oxoethyl)amino]-1-oxopropan-2-yl}-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Synonyms:gadolinium 2,2',2''-(10-{1-[(2-{[6-(4-ethynylphenyl)hexyl]amino}-2-oxoethyl)amino]-1-oxopropan-2-yl}-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Chemical Property of gadolinium 2,2',2''-(10-{1-[(2-{[6-(4-ethynylphenyl)hexyl]amino}-2-oxoethyl)amino]-1-oxopropan-2-yl}-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Technology Process of gadolinium 2,2',2''-(10-{1-[(2-{[6-(4-ethynylphenyl)hexyl]amino}-2-oxoethyl)amino]-1-oxopropan-2-yl}-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

There total 4 articles about gadolinium 2,2',2''-(10-{1-[(2-{[6-(4-ethynylphenyl)hexyl]amino}-2-oxoethyl)amino]-1-oxopropan-2-yl}-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621926-54-2
methyl 6-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)hexanoate

: 1621926-58-6
gadolinium 2,2',2''-(10-{1-[(2-{[6-(4-ethynylphenyl)hexyl]amino}-2-oxoethyl)amino]-1-oxopropan-2-yl}-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 96 h / 45 °C

2.1: diisobutylaluminium hydride / diethyl ether; toluene / 2 h / -90 - -70 °C

3.1: ammonium acetate; acetic acid / methanol / 0.17 h

3.2: 16 h

4.1: N-ethyl-N,N-diisopropylamine; HATU / dimethylsulfoxide-d6; N,N-dimethyl-formamide / 17 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ammonium acetate; diisobutylaluminium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dimethylsulfoxide-d6; diethyl ether; N,N-dimethyl-formamide; toluene;

Reference yield:

: 113379-10-5
methyl 6-(4-hydroxyphenyl)hexanoate

: 1621926-58-6
gadolinium 2,2',2''-(10-{1-[(2-{[6-(4-ethynylphenyl)hexyl]amino}-2-oxoethyl)amino]-1-oxopropan-2-yl}-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 19 h / 0 - 20 °C

2.1: copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 96 h / 45 °C

3.1: diisobutylaluminium hydride / diethyl ether; toluene / 2 h / -90 - -70 °C

4.1: ammonium acetate; acetic acid / methanol / 0.17 h

4.2: 16 h

5.1: N-ethyl-N,N-diisopropylamine; HATU / dimethylsulfoxide-d6; N,N-dimethyl-formamide / 17 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ammonium acetate; diisobutylaluminium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dimethylsulfoxide-d6; diethyl ether; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1621926-55-3
methyl 6-{4-[(trimethylsilyl)ethynyl]phenyl}hexanoate

: 1621926-58-6
gadolinium 2,2',2''-(10-{1-[(2-{[6-(4-ethynylphenyl)hexyl]amino}-2-oxoethyl)amino]-1-oxopropan-2-yl}-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / diethyl ether; toluene / 2 h / -90 - -70 °C

2.1: ammonium acetate; acetic acid / methanol / 0.17 h

2.2: 16 h

3.1: N-ethyl-N,N-diisopropylamine; HATU / dimethylsulfoxide-d6; N,N-dimethyl-formamide / 17 h / 20 °C

With ammonium acetate; diisobutylaluminium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dimethylsulfoxide-d6; diethyl ether; N,N-dimethyl-formamide; toluene;