C₂₂H₃₄O₃

Base Information

• Chemical Name: C₂₂H₃₄O₃
• CAS No.: 1312543-66-0
• Molecular Formula: C₂₂H₃₄O₃
• Molecular Weight: 346.51
• Mol file: 1312543-66-0.mol

Synonyms:C₂₂H₃₄O₃

Chemical Property of C₂₂H₃₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₃₄O₃

There total 11 articles about C₂₂H₃₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C24H36O4 (1312543-65-9) → C22H34O3 (1312543-66-0)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 - 0 ℃; for 1h;

DOI:10.1016/j.tetlet.2011.04.008

Reference yield:

(2R)-2-[(4S,5S)-5-ethyl-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-1-ol (910228-56-7) → C22H34O3 (1312543-66-0)

Guidance literature:

Multi-step reaction with 11 steps

1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 0.33 h / 50 °C

2: lithium chloride; lithium diisopropyl amide / tetrahydrofuran / 14 h / -78 - 20 °C

3: ammonia borane; lithium diisopropyl amide / tetrahydrofuran / 4 h / -78 - 20 °C

4: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 - 20 °C

5: diisobutylaluminium hydride / dichloromethane / 2 h / -40 - -10 °C

6: sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1.5 h / 0 - 20 °C

7: sodium hexamethyldisilazane / tetrahydrofuran / 18 h / -78 - 20 °C

8: tetrabutyl ammonium fluoride / tetrahydrofuran / 10 h / 0 - 20 °C

9: sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1.5 h / 0 - 20 °C

10: benzoic acid / toluene / 0.25 h / 90 °C

11: diisobutylaluminium hydride / dichloromethane / 1 h / -78 - 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; ammonia borane; tetrabutyl ammonium fluoride; iodine; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; diisobutylaluminium hydride; triphenylphosphine; benzoic acid; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; 2: Myers alkylation reaction / 7: Wittig reaction / 10: Wittig reaction;

DOI:10.1016/j.tetlet.2011.04.008

Reference yield:

C19H30O4 (1312543-60-4) → C22H34O3 (1312543-66-0)

Guidance literature:

Multi-step reaction with 8 steps

1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 - 20 °C

2: diisobutylaluminium hydride / dichloromethane / 2 h / -40 - -10 °C

3: sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1.5 h / 0 - 20 °C

4: sodium hexamethyldisilazane / tetrahydrofuran / 18 h / -78 - 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 10 h / 0 - 20 °C

6: sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1.5 h / 0 - 20 °C

7: benzoic acid / toluene / 0.25 h / 90 °C

8: diisobutylaluminium hydride / dichloromethane / 1 h / -78 - 0 °C

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; diisobutylaluminium hydride; benzoic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; 4: Wittig reaction / 7: Wittig reaction;

DOI:10.1016/j.tetlet.2011.04.008

upstream raw materials:

(2R)-2-[(4S,5S)-5-ethyl-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-1-ol

C₁₉H₃₀O₄

C₂₅H₄₄O₄Si

C₂₅H₄₆O₄Si

Downstream raw materials:

C₂₂H₃₄O₄

C₂₂H₃₆O₄

C₃₄H₆₄O₄Si₂

(3S,4R,6R,7R,8R)-3-(tert-butyldimethylsilyloxy)-8-ethyl-7-(4-methoxybenzyloxy)-4,6-dimethyldec-9-en-1-ol