3-(4-CHLOROPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXYLIC ACID

Base Information

• Chemical Name: 3-(4-CHLOROPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXYLIC ACID
• CAS No.: 86662-15-9
• Molecular Formula: C₁₅H₉ClN₂O₃
• Molecular Weight: 300.701
• Mol file: 86662-15-9.mol

Synonyms:3-(4-chlorophenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid

Chemical Property of 3-(4-CHLOROPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXYLIC ACID

Chemical Property:

Purity/Quality:

3-(4-Chlorophenyl)-4-oxo-3,4-dihydro-1-phthalazinecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-CHLOROPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXYLIC ACID

There total 5 articles about 3-(4-CHLOROPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(4-Chlorophenylhydrazono)-1H-2-benzopyran-1,3(4H)-dione (86671-86-5) → 3-(4-chlorophenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid (86662-15-9)

Guidance literature:

With sodium hydroxide; for 0.333333h; Heating;

DOI:10.1055/s-1983-30365

Reference yield: 74.0%

methyl 4-oxo-3-(4-chlorophenyl)-3,4-dihydrophthalazine-1-carboxylate (97458-95-2) → 3-(4-chlorophenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid (86662-15-9)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; methanol; water; at 60 ℃; for 4h;

DOI:10.1016/j.tet.2012.10.010

Reference yield: 30.62%

phthalonic acid (528-46-1) + N-4-chlorophenylhydrazine (1073-69-4) → 3-(4-chlorophenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid (86662-15-9)

Guidance literature:

In ethanol; water; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2016.04.062

upstream raw materials:

4-(4-Chlorophenylhydrazono)-1H-2-benzopyran-1,3(4H)-dione

4-chloro-aniline

homophthalic anhydride

methyl 4-oxo-3-(4-chlorophenyl)-3,4-dihydrophthalazine-1-carboxylate

Downstream raw materials:

3-(4-Chloro-phenyl)-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid o-tolylamide

3-(4-Chloro-phenyl)-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid (2-chloro-phenyl)-amide

3-(4-Chloro-phenyl)-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid (3-chloro-phenyl)-amide

3-(4-chlorophenyl)-4-oxo-3,4-dihydrophthalazine-1-carbonyl azide