1-(5-(7-chloro-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea

Base Information

Chemical Name:1-(5-(7-chloro-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea
CAS No.:1442474-49-8
Molecular Formula:C₂₅H₂₂ClFN₄O₂
Molecular Weight:464.927
Hs Code.:

Synonyms:1-(5-(7-chloro-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea

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Chemical Property of 1-(5-(7-chloro-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea

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Technology Process of 1-(5-(7-chloro-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea

There total 6 articles about 1-(5-(7-chloro-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1442470-59-8
3-(5-amino-4-fluoro-2-methylphenyl)-7-chloro-1-isopropyl-1,6-naphthyridin-2(1H)-one

: 103-71-9
phenyl isocyanate

: 1442474-49-8
1-(5-(7-chloro-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 407640-40-8
2-(4-fluoro-2-methylphenyl)acetic acid

: 1442474-49-8
1-(5-(7-chloro-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid / 0.25 h / -15 - 5 °C

2: sulfuric acid / 2.5 h / 85 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 2660.18 Torr

4: caesium carbonate / N,N-dimethyl-formamide / 100 °C

5: triethylamine / tetrahydrofuran / 3 h / 20 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; caesium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1012880-03-3
2-(4-fluoro-2-methyl-5-nitrophenyl)acetic acid

: 1442474-49-8
1-(5-(7-chloro-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 2.5 h / 85 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 2660.18 Torr

3: caesium carbonate / N,N-dimethyl-formamide / 100 °C

4: triethylamine / tetrahydrofuran / 3 h / 20 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;