(+/-)-9-{2-amino-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine

Base Information

• Chemical Name: (+/-)-9-{2-amino-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine
• CAS No.: 918868-99-2
• Molecular Formula: C₂₈H₂₇ClN₆O₂
• Molecular Weight: 515.014
• Mol file: 918868-99-2.mol

Synonyms:(+/-)-9-{2-amino-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine

Chemical Property of (+/-)-9-{2-amino-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-9-{2-amino-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine

There total 7 articles about (+/-)-9-{2-amino-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(+/-)-9-{2-azido-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine (918868-97-0) → (+/-)-9-{2-amino-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine (918868-99-2)

Guidance literature:

(+/-)-9-{2-azido-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine; With triphenylphosphine; In tetrahydrofuran;

With water; In tetrahydrofuran; for 3h; Heating;

DOI:10.1135/cccc20060015

Reference yield:

benzoic acid 2-hydroxy-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester → (+/-)-9-{2-amino-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine (918868-99-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 21.43 g / pyridine / 2 h

2.1: NaN₃ / dimethylformamide / 100 °C

3.1: 7.44 g / NaOH / methanol

4.1: 45 percent / diisopropyl azodicarboxylate / tetrahydrofuran / 20 °C

5.1: 82 percent / H₂O / tetrahydrofuran / 48 h / Heating

6.1: Ph₃P / tetrahydrofuran

6.2: 91 percent / H₂O / tetrahydrofuran / 3 h / Heating

With pyridine; sodium hydroxide; sodium azide; di-isopropyl azodicarboxylate; water; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;

DOI:10.1135/cccc20060015

Reference yield:

(+/-)-2-azido-3-[(4-methoxytrityl)oxy]propan-1-ol (918868-72-1) → (+/-)-9-{2-amino-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine (918868-99-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 45 percent / diisopropyl azodicarboxylate / tetrahydrofuran / 20 °C

2.1: 82 percent / H₂O / tetrahydrofuran / 48 h / Heating

3.1: Ph₃P / tetrahydrofuran

3.2: 91 percent / H₂O / tetrahydrofuran / 3 h / Heating

With di-isopropyl azodicarboxylate; water; triphenylphosphine; In tetrahydrofuran; 1.1: Mitsunobu reaction;

DOI:10.1135/cccc20060015

upstream raw materials:

(+/-)-9-{2-azido-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine

(+/-)-2-azido-3-[(4-methoxytrityl)oxy]propan-1-ol

(+/-)-2-(mesyloxy)-3-[(4-methoxytrityl)oxy]propyl benzoate

C₄₆H₃₈ClN₈O₂P