(1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde

Base Information

• Chemical Name: (1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde
• CAS No.: 304859-87-8
• Molecular Formula: C₁₇H₂₃BrO₃
• Molecular Weight: 355.272
• Mol file: 304859-87-8.mol

Synonyms:(1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde

Chemical Property of (1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde

There total 6 articles about (1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)phenyl-1-methanol (328533-38-6) → (1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde (304859-87-8)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1055/s-2001-9760

Reference yield: 75.0%

dimethyl sulfate (77-78-1) + (1'S)-2-bromo-3,4-dihydroxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde (304859-86-7) → (1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde (304859-87-8)

Guidance literature:

With potassium carbonate; In acetone;

DOI:10.1021/ja001455r

Reference yield:

(1'S)-3,4-dihydroxy-5-(1,2,2-trimethylcyclopentyl)benzaldehyde (185967-11-7) → (1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde (304859-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / Br₂ / CH₂Cl₂

2: 75 percent / K₂CO₃ / acetone

With bromine; potassium carbonate; In dichloromethane; acetone;

DOI:10.1021/ja001455r

upstream raw materials:

(1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)phenyl-1-methanol

dimethyl sulfate

(1'S)-2-bromo-3,4-dihydroxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde

(1'S)-3,4-dihydroxy-5-(1,2,2-trimethylcyclopentyl)benzaldehyde

Downstream raw materials:

(1'S)-3,4-Dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde

(1'S)-2-bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzoic acid