(1R,2S,3R,5S)-2,3-Bis-(3-chloro-phenyl)-5-hydroxy-cyclopentanecarboxylic acid methyl ester

Base Information

Chemical Name:(1R,2S,3R,5S)-2,3-Bis-(3-chloro-phenyl)-5-hydroxy-cyclopentanecarboxylic acid methyl ester
CAS No.:132455-73-3
Molecular Formula:C₁₉H₁₈Cl₂O₃
Molecular Weight:365.256
Hs Code.:

Synonyms:(1R,2S,3R,5S)-2,3-Bis-(3-chloro-phenyl)-5-hydroxy-cyclopentanecarboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S,3R,5S)-2,3-Bis-(3-chloro-phenyl)-5-hydroxy-cyclopentanecarboxylic acid methyl ester

Chemical Property:

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Technology Process of (1R,2S,3R,5S)-2,3-Bis-(3-chloro-phenyl)-5-hydroxy-cyclopentanecarboxylic acid methyl ester

There total 2 articles about (1R,2S,3R,5S)-2,3-Bis-(3-chloro-phenyl)-5-hydroxy-cyclopentanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132455-72-2,132490-29-0,132490-30-3
Methyl (+/-)-4,5-bis(3-chlorophenyl)-2-oxocyclopentanecarboxylate

: 132490-28-9
(1S,2R,3S,5S)-2,3-Bis-(3-chloro-phenyl)-5-hydroxy-cyclopentanecarboxylic acid methyl ester

: 132455-73-3
(1R,2S,3R,5S)-2,3-Bis-(3-chloro-phenyl)-5-hydroxy-cyclopentanecarboxylic acid methyl ester

Guidance literature:: With BINAP-Ru(II) (Komplex 3); hydrogen; In methanol; dichloromethane; at 60 ℃; for 120h; under 69873.2 Torr; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)97275-7

Reference yield:

: 42175-03-1
methyl ester of m-chlorocinnamic acid

: 132455-73-3
(1R,2S,3R,5S)-2,3-Bis-(3-chloro-phenyl)-5-hydroxy-cyclopentanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 34 percent / electrochemical cyclodimerization

2: H₂; ⁽¹⁺⁾*I^(1-) / CH₂Cl₂; methanol / 120 h / 60 °C / 66195.7 - 69873.2 Torr

With (1+)*I(1-); hydrogen; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)97275-7