6-(4-nitrophenyl)-5-hexyn-1-azide

Base Information

• Chemical Name: 6-(4-nitrophenyl)-5-hexyn-1-azide
• CAS No.: 1450663-58-7
• Molecular Formula: C₁₂H₁₂N₄O₂
• Molecular Weight: 244.253
• Mol file: 1450663-58-7.mol

Synonyms:6-(4-nitrophenyl)-5-hexyn-1-azide

Chemical Property of 6-(4-nitrophenyl)-5-hexyn-1-azide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-(4-nitrophenyl)-5-hexyn-1-azide

There total 2 articles about 6-(4-nitrophenyl)-5-hexyn-1-azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H15NO5S (1450663-55-4) → 6-(4-nitrophenyl)-5-hexyn-1-azide (1450663-58-7)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 50 ℃; for 3h;

DOI:10.1002/chem.201202391

Reference yield:

4-(6-hydroxy-hex-1-ynyl)-nitrobenzene → 6-(4-nitrophenyl)-5-hexyn-1-azide (1450663-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1.08 h / 0 - 20 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 3 h / 50 °C

With sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.201202391

Reference yield: 75.0%

6-(4-nitrophenyl)-5-hexyn-1-azide (1450663-58-7) → 6-(4-nitrophenyl)-5-hexyn-1-ammonium chloride (1450663-60-1)

Guidance literature:

6-(4-nitrophenyl)-5-hexyn-1-azide; With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1002/chem.201202391

upstream raw materials:

C₁₃H₁₅NO₅S

Downstream raw materials:

6-(4-nitrophenyl)-5-hexyn-1-ammonium chloride