4-[5-(Aminomethyl)-2-oxo-3-oxazolidinyl]benzonitrile

Base Information

Chemical Name:4-[5-(Aminomethyl)-2-oxo-3-oxazolidinyl]benzonitrile
CAS No.:130641-98-4
Molecular Formula:C₁₁H₁₁N₃O₂
Molecular Weight:217.227
Hs Code.:
DSSTox Substance ID:DTXSID301216627

Synonyms:4-[5-(Aminomethyl)-2-oxo-3-oxazolidinyl]benzonitrile;DTXSID301216627;130641-98-4

Suppliers and Price of 4-[5-(Aminomethyl)-2-oxo-3-oxazolidinyl]benzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[5-(Aminomethyl)-2-oxo-3-oxazolidinyl]benzonitrile

Chemical Property:

XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:217.085126602
Heavy Atom Count:16
Complexity:314

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(OC(=O)N1C2=CC=C(C=C2)C#N)CN

Technology Process of 4-[5-(Aminomethyl)-2-oxo-3-oxazolidinyl]benzonitrile

There total 5 articles about 4-[5-(Aminomethyl)-2-oxo-3-oxazolidinyl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(5-Azidomethyl-2-oxo-oxazolidin-3-yl)-benzonitrile

: 130641-98-4
4-(5-Aminomethyl-2-oxo-oxazolidin-3-yl)-benzonitrile

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; for 5h; under 760 Torr;

Reference yield:

: 64589-85-1
4-(2-oxo-5-hydroxymethyloxazolidin-3-yl)benzonitrile

: 130641-98-4
4-(5-Aminomethyl-2-oxo-oxazolidin-3-yl)-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 0 - 5 °C

2: sodium azide / dimethylformamide / 12 h / 40 °C

3: H₂ / 10percent Pd/C / methanol; ethyl acetate / 5 h / 760 Torr

With pyridine; sodium azide; hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 130641-97-3
3-<(4-cyanophenyl)amino>-1,2-propanediol

: 130641-98-4
4-(5-Aminomethyl-2-oxo-oxazolidin-3-yl)-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / sodium methoxide / methanol

2: pyridine / 0 - 5 °C

3: sodium azide / dimethylformamide / 12 h / 40 °C

4: H₂ / 10percent Pd/C / methanol; ethyl acetate / 5 h / 760 Torr

With pyridine; sodium azide; hydrogen; sodium methylate; palladium on activated charcoal; In methanol; ethyl acetate; N,N-dimethyl-formamide;