2-(1-methyl-2-pyridin-2-ylethyl)-3-oxo-N-[4-(trifluoromethoxy)benzyl]isoindoline-1-carboxamide

Base Information

Chemical Name:2-(1-methyl-2-pyridin-2-ylethyl)-3-oxo-N-[4-(trifluoromethoxy)benzyl]isoindoline-1-carboxamide
CAS No.:1198116-64-1
Molecular Formula:C₂₅H₂₂F₃N₃O₃
Molecular Weight:469.463
Hs Code.:

Synonyms:2-(1-methyl-2-pyridin-2-ylethyl)-3-oxo-N-[4-(trifluoromethoxy)benzyl]isoindoline-1-carboxamide

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Chemical Property of 2-(1-methyl-2-pyridin-2-ylethyl)-3-oxo-N-[4-(trifluoromethoxy)benzyl]isoindoline-1-carboxamide

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Technology Process of 2-(1-methyl-2-pyridin-2-ylethyl)-3-oxo-N-[4-(trifluoromethoxy)benzyl]isoindoline-1-carboxamide

There total 3 articles about 2-(1-methyl-2-pyridin-2-ylethyl)-3-oxo-N-[4-(trifluoromethoxy)benzyl]isoindoline-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1198103-41-1
2-(1-methyl-2-pyridin-2-ylethyl)-3-oxoisoindoline-1-carboxylic acid

: 93919-56-3
4-(trifluoromethoxy)benzyl amine

: 1198116-64-1
2-(1-methyl-2-pyridin-2-ylethyl)-3-oxo-N-[4-(trifluoromethoxy)benzyl]isoindoline-1-carboxamide

Guidance literature:: 2-(1-methyl-2-pyridin-2-ylethyl)-3-oxoisoindoline-1-carboxylic acid; With triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

4-(trifluoromethoxy)benzyl amine; In N,N-dimethyl-formamide; at 45 ℃; Inert atmosphere;
DOI:10.1021/jm300623u

Reference yield:

: 51038-40-5,64144-48-5
1-(methyl-2-pyridin-2-ylethyl)amine

: 1198116-64-1
2-(1-methyl-2-pyridin-2-ylethyl)-3-oxo-N-[4-(trifluoromethoxy)benzyl]isoindoline-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile / 0 - 20 °C / Cooling with ice; Inert atmosphere

2.1: sodium hydroxide / methanol / 0.25 h / 20 °C

3.1: triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 45 °C / Inert atmosphere

With triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm300623u

Reference yield:

: 79016-11-8
ethyl 2-(1-bromo-2-ethoxy-2-oxoethyl)benzoate

: 1198116-64-1
2-(1-methyl-2-pyridin-2-ylethyl)-3-oxo-N-[4-(trifluoromethoxy)benzyl]isoindoline-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile / 0 - 20 °C / Cooling with ice; Inert atmosphere

2.1: sodium hydroxide / methanol / 0.25 h / 20 °C

3.1: triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 45 °C / Inert atmosphere

With triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm300623u