tert-butoxycarbonylamino-thioacetic acid S-[3-acetylsulfanyl-7-({2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-carbamoyl)-heptyl] ester

Base Information

Chemical Name:tert-butoxycarbonylamino-thioacetic acid S-[3-acetylsulfanyl-7-({2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-carbamoyl)-heptyl] ester
CAS No.:913184-73-3
Molecular Formula:C₃₀H₄₃N₃O₈S₃
Molecular Weight:669.885
Hs Code.:

<i>tert</i>-butoxycarbonylamino-thioacetic acid <i>S</i>-[3-acetylsulfanyl-7-({2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-carbamoyl)-heptyl] ester

Synonyms:tert-butoxycarbonylamino-thioacetic acid S-[3-acetylsulfanyl-7-({2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-carbamoyl)-heptyl] ester

Suppliers and Price of tert-butoxycarbonylamino-thioacetic acid S-[3-acetylsulfanyl-7-({2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-carbamoyl)-heptyl] ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of tert-butoxycarbonylamino-thioacetic acid S-[3-acetylsulfanyl-7-({2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-carbamoyl)-heptyl] ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butoxycarbonylamino-thioacetic acid S-[3-acetylsulfanyl-7-({2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-carbamoyl)-heptyl] ester

There total 8 articles about tert-butoxycarbonylamino-thioacetic acid S-[3-acetylsulfanyl-7-({2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-carbamoyl)-heptyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 905991-40-4
S-{8-[(2-{4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy}ethyl)(methyl)amino]-3-mercapto-8-oxooctyl} [(tert-butoxycarbonyl)amino]ethanethioate

: 108-24-7
acetic anhydride

: 913184-73-3
tert-butoxycarbonylamino-thioacetic acid S-[3-acetylsulfanyl-7-({2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-carbamoyl)-heptyl] ester

Guidance literature:: With pyridine; at 20 ℃; for 2h;
DOI:10.1021/jm0510880

Reference yield:

: 292615-76-0
N-(2-{4-[2,4-dioxo(1,3-thiazolidin-5-yl)methyl]phenoxy}ethyl)-5-(1,2-dithiolan-3-yl)-N-methylpentanamide

: 913184-73-3
tert-butoxycarbonylamino-thioacetic acid S-[3-acetylsulfanyl-7-({2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-carbamoyl)-heptyl] ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / NaBH₄ / tetrahydrofuran; H₂O / 1 h / 0 °C

2: 21 percent / Et₃N; hydroxybenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

3: 66 percent / pyridine / 2 h / 20 °C

With pyridine; sodium tetrahydroborate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm0510880

Reference yield:

: 5-{4-[2-(methylamino)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione hydrochloride

: 913184-73-3
tert-butoxycarbonylamino-thioacetic acid S-[3-acetylsulfanyl-7-({2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-carbamoyl)-heptyl] ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N; isopropyl chloroformate / CH₂Cl₂ / 0.17 h / 0 °C

1.2: 72 percent / Et₃N / CH₂Cl₂; toluene / 1 h / 0 °C

2.1: 86 percent / NaBH₄ / tetrahydrofuran; H₂O / 1 h / 0 °C

3.1: 21 percent / Et₃N; hydroxybenzotriazole; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

4.1: 66 percent / pyridine / 2 h / 20 °C

With pyridine; sodium tetrahydroborate; benzotriazol-1-ol; isopropyl chloroformate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm0510880