4-[2-methoxy-5-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenoxy]-N-methylbenzamide

Base Information

Chemical Name:4-[2-methoxy-5-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenoxy]-N-methylbenzamide
CAS No.:1453854-21-1
Molecular Formula:C₂₁H₂₅NO₈
Molecular Weight:419.431
Hs Code.:

Synonyms:4-[2-methoxy-5-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenoxy]-N-methylbenzamide

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Chemical Property of 4-[2-methoxy-5-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenoxy]-N-methylbenzamide

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Technology Process of 4-[2-methoxy-5-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenoxy]-N-methylbenzamide

There total 5 articles about 4-[2-methoxy-5-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenoxy]-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.46%

: [(2R,3R,4R,5R,6R)-3,4,5-triacetoxy-6-[4-methoxy-3-[4-(methylcarbamoyl)phenoxy]phenyl]tetrahydropyran-2-yl]methyl acetate

: 1453854-21-1
4-[2-methoxy-5-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenoxy]-N-methylbenzamide

Guidance literature:: With sodium methylate; In methanol; at 20 ℃;

Reference yield:

: 1453856-18-2
[(2R,3R,4R,5R,6R)-3,4,5-triacetoxy-6-(3-hydroxy-4-methoxyphenyl)tetrahydropyran-2-yl]methyl acetate

: 1453854-21-1
4-[2-methoxy-5-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenoxy]-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper diacetate; 2,6-dimethylpyridine / dichloromethane / 48 h / 20 °C / Molecular sieve

2: sodium methylate / methanol / 20 °C

With 2,6-dimethylpyridine; sodium methylate; copper diacetate; In methanol; dichloromethane;

Reference yield:

: 900152-53-6
[3-[tert-butyl(dimethyl)silyl]oxy-4-methoxyphenyl]boronic acid

: 1453854-21-1
4-[2-methoxy-5-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenoxy]-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium diacetate / acetonitrile / 20 °C

2.1: 4-methylmorpholine N-oxide; methanesulfonamide; osmium(VIII) oxide; 2,6-dimethylpyridine / water; tert-butyl alcohol / 24 h / 20 °C

3.1: pyridine; dmap / 2 h / 20 °C

3.2: 20 °C

4.1: copper diacetate; 2,6-dimethylpyridine / dichloromethane / 48 h / 20 °C / Molecular sieve

5.1: sodium methylate / methanol / 20 °C

With pyridine; 2,6-dimethylpyridine; dmap; osmium(VIII) oxide; methanesulfonamide; sodium methylate; copper diacetate; palladium diacetate; 4-methylmorpholine N-oxide; In methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;