(5S)-7-(5-chloro-2-fluorophenyl)-3-(tetrahydro-2H-pyran-4-yl)-spiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazol]-2'-amine

Base Information

Chemical Name:(5S)-7-(5-chloro-2-fluorophenyl)-3-(tetrahydro-2H-pyran-4-yl)-spiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazol]-2'-amine
CAS No.:1215867-72-3
Molecular Formula:C₂₅H₂₁ClFN₃O₃
Molecular Weight:465.911
Hs Code.:

Synonyms:(5S)-7-(5-chloro-2-fluorophenyl)-3-(tetrahydro-2H-pyran-4-yl)-spiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazol]-2'-amine

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Chemical Property of (5S)-7-(5-chloro-2-fluorophenyl)-3-(tetrahydro-2H-pyran-4-yl)-spiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazol]-2'-amine

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Technology Process of (5S)-7-(5-chloro-2-fluorophenyl)-3-(tetrahydro-2H-pyran-4-yl)-spiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazol]-2'-amine

There total 5 articles about (5S)-7-(5-chloro-2-fluorophenyl)-3-(tetrahydro-2H-pyran-4-yl)-spiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazol]-2'-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215867-75-6
(S)-2'-amino-3-(tetrahydro-2H-pyran-4-yl)-5′H-spiro[chromeno[2,3-b]pyridine-5,4′-oxazol]-7-yl trifluoromethanesulfonate

: 352535-83-2
5-chloro-2-fluorophenylboronic acid

: 1215867-72-3
(5S)-7-(5-chloro-2-fluorophenyl)-3-(tetrahydro-2H-pyran-4-yl)-spiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazol]-2'-amine

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 80 ℃; for 1.5h; Inert atmosphere; Sealed;

Reference yield:

: 287944-16-5
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyran

: 1215867-72-3
(5S)-7-(5-chloro-2-fluorophenyl)-3-(tetrahydro-2H-pyran-4-yl)-spiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazol]-2'-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 18 h / 80 °C / Sealed vial

2: hydrogen / palladium on activated charcoal / methanol / 60 h

3: triethylamine / dichloromethane / 4 h

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1.5 h / 80 °C / Inert atmosphere; Sealed

With hydrogen; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki Coupling / 4: Suzuki Coupling;

Reference yield:

: 1215867-38-1
(S)-2'-amino-3-bromo-5'H-spiro[chromeno[2,3-b]pyridin-5,4'-oxazol]-7-ol

: 1215867-72-3
(5S)-7-(5-chloro-2-fluorophenyl)-3-(tetrahydro-2H-pyran-4-yl)-spiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazol]-2'-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 18 h / 80 °C / Sealed vial

2: hydrogen / palladium on activated charcoal / methanol / 60 h

3: triethylamine / dichloromethane / 4 h

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1.5 h / 80 °C / Inert atmosphere; Sealed

With hydrogen; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki Coupling / 4: Suzuki Coupling;