1-(4-chlorophenyl)-3-((E)-3-dimethylaminoacryloyl)-1H-pyrazole-4-carbonitrile

Base Information

• Chemical Name: 1-(4-chlorophenyl)-3-((E)-3-dimethylaminoacryloyl)-1H-pyrazole-4-carbonitrile
• CAS No.: 868701-58-0
• Molecular Formula: C₁₅H₁₃ClN₄O
• Molecular Weight: 300.747

Synonyms:1-(4-chlorophenyl)-3-((E)-3-dimethylaminoacryloyl)-1H-pyrazole-4-carbonitrile

Chemical Property of 1-(4-chlorophenyl)-3-((E)-3-dimethylaminoacryloyl)-1H-pyrazole-4-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 1-(4-chlorophenyl)-3-((E)-3-dimethylaminoacryloyl)-1H-pyrazole-4-carbonitrile

There total 2 articles about 1-(4-chlorophenyl)-3-((E)-3-dimethylaminoacryloyl)-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-acetyl-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile (868701-53-5) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 1-(4-chlorophenyl)-3-((E)-3-dimethylaminoacryloyl)-1H-pyrazole-4-carbonitrile (868701-58-0)

Guidance literature:

In xylene; for 3h; Heating;

DOI:10.1002/jhet.5570420623

Reference yield:

1-chloro-1-[(4-chlorophenyl)hydrazono]propanone (18247-78-4,1338563-31-7) → 1-(4-chlorophenyl)-3-((E)-3-dimethylaminoacryloyl)-1H-pyrazole-4-carbonitrile (868701-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / Et₃N / ethanol / 4 h / Heating

2: 75 percent / xylene / 3 h / Heating

With triethylamine; In ethanol; xylene;

DOI:10.1002/jhet.5570420623

Reference yield: 83.0%

1-(4-chlorophenyl)-3-((E)-3-dimethylaminoacryloyl)-1H-pyrazole-4-carbonitrile (868701-58-0) + [1,4]naphthoquinone (130-15-4) → 1-(4-chlorophenyl)-3-(5-hydroxynaphtho[1,2-b]furan-3-carbonyl)-1H-pyrazole-4-carbonitrile

Guidance literature:

In acetic acid; at 20 ℃;

DOI:10.1002/jhet.5570420623

upstream raw materials:

3-acetyl-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile

N,N-dimethyl-formamide dimethyl acetal

1-chloro-1-[(4-chlorophenyl)hydrazono]propanone

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