1-(3-Methyl-2-nitro-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone

Base Information

• Chemical Name: 1-(3-Methyl-2-nitro-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone
• CAS No.: 111054-13-8
• Molecular Formula: C₂₇H₂₂NO₃P
• Molecular Weight: 439.45
• Mol file: 111054-13-8.mol

Synonyms:1-(3-Methyl-2-nitro-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone

Chemical Property of 1-(3-Methyl-2-nitro-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-Methyl-2-nitro-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone

There total 3 articles about 1-(3-Methyl-2-nitro-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

3-(3-Methyl-2-nitro-phenyl)-3-oxo-2-(triphenyl-λ5-phosphanylidene)-propionic acid tert-butyl ester (111054-10-5) → 1-(3-Methyl-2-nitro-phenyl)-2-(triphenyl-λ5-phosphanylidene)-ethanone (111054-13-8)

Guidance literature:

With sulfuric acid; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1055/s-1987-27921

Reference yield:

3-methyl-2-nitrobenzoyl chloride (50424-93-6) → 1-(3-Methyl-2-nitro-phenyl)-2-(triphenyl-λ5-phosphanylidene)-ethanone (111054-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / benzene / 16 h / Ambient temperature

2: 91.5 percent / 85percent aq. H₂SO₄ / CH₂Cl₂ / 3 h / Ambient temperature

With sulfuric acid; In dichloromethane; benzene;

DOI:10.1055/s-1987-27921

Reference yield:

(tert-Butoxycarbonylmethylene)triphenylphosphorane (86302-43-4,35000-38-5) → 1-(3-Methyl-2-nitro-phenyl)-2-(triphenyl-λ5-phosphanylidene)-ethanone (111054-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / benzene / 16 h / Ambient temperature

2: 91.5 percent / 85percent aq. H₂SO₄ / CH₂Cl₂ / 3 h / Ambient temperature

With sulfuric acid; In dichloromethane; benzene;

DOI:10.1055/s-1987-27921

upstream raw materials:

3-(3-Methyl-2-nitro-phenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-propionic acid tert-butyl ester

3-methyl-2-nitrobenzoyl chloride

(tert-Butoxycarbonylmethylene)triphenylphosphorane

Downstream raw materials:

8-Methyl-3-(triphenyl-λ⁵-phosphanylidene)-3H-cinnolin-4-one

1-(2-Amino-3-methyl-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone