1-[4-((1R,2S)-1,2-Diphenyl-butyl)-phenoxy]-2,6-difluoro-3,5-bis-((R)-1-phenyl-ethoxy)-4-trifluoromethyl-benzene

Base Information

Chemical Name:1-[4-((1R,2S)-1,2-Diphenyl-butyl)-phenoxy]-2,6-difluoro-3,5-bis-((R)-1-phenyl-ethoxy)-4-trifluoromethyl-benzene
CAS No.:109640-38-2
Molecular Formula:C₄₅H₃₉F₅O₃
Molecular Weight:722.795
Hs Code.:

Synonyms:1-[4-((1R,2S)-1,2-Diphenyl-butyl)-phenoxy]-2,6-difluoro-3,5-bis-((R)-1-phenyl-ethoxy)-4-trifluoromethyl-benzene

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Chemical Property of 1-[4-((1R,2S)-1,2-Diphenyl-butyl)-phenoxy]-2,6-difluoro-3,5-bis-((R)-1-phenyl-ethoxy)-4-trifluoromethyl-benzene

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Technology Process of 1-[4-((1R,2S)-1,2-Diphenyl-butyl)-phenoxy]-2,6-difluoro-3,5-bis-((R)-1-phenyl-ethoxy)-4-trifluoromethyl-benzene

There total 9 articles about 1-[4-((1R,2S)-1,2-Diphenyl-butyl)-phenoxy]-2,6-difluoro-3,5-bis-((R)-1-phenyl-ethoxy)-4-trifluoromethyl-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1517-69-7
(R)-1-phenylethanol

: 109640-36-0
1-[4-((1R,2S)-1,2-Diphenyl-butyl)-phenoxy]-2,3,5,6-tetrafluoro-4-trifluoromethyl-benzene

: 109640-38-2
1-[4-((1R,2S)-1,2-Diphenyl-butyl)-phenoxy]-2,6-difluoro-3,5-bis-((R)-1-phenyl-ethoxy)-4-trifluoromethyl-benzene

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;
DOI:10.1021/jm00393a014

Reference yield:

: 434-64-0
perfluorotoluene

: 109640-38-2
1-[4-((1R,2S)-1,2-Diphenyl-butyl)-phenoxy]-2,6-difluoro-3,5-bis-((R)-1-phenyl-ethoxy)-4-trifluoromethyl-benzene

Guidance literature:: Multi-step reaction with 2 steps

1: Bu₄N⁺*HSO₄^-, 1.5 M aq. NaOH / CH₂Cl₂ / 2 h / 22 °C

2: 53 percent / NaH / dimethylformamide / 0.5 h

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00393a014

Reference yield:

: 938-79-4
(2R)-2-phenylbutanoic acid

: 109640-38-2
1-[4-((1R,2S)-1,2-Diphenyl-butyl)-phenoxy]-2,6-difluoro-3,5-bis-((R)-1-phenyl-ethoxy)-4-trifluoromethyl-benzene

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / (CF₃CO)2O / 4 h / 22 °C

2: 61 percent / diethyl ether / 22 h / 22 °C

3: 1.) NH₃(liq.), Li, 2.) Py*HCl / 1.) THF, t-BuOH, reflux, 15 min, 2.) 220 deg C, 2 h

4: Bu₄N⁺*HSO₄^-, 1.5 M aq. NaOH / CH₂Cl₂ / 2 h / 22 °C

5: 53 percent / NaH / dimethylformamide / 0.5 h

With sodium hydroxide; ammonia; tetra(n-butyl)ammonium hydrogensulfate; pyridine hydrochloride; lithium; sodium hydride; trifluoroacetic anhydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00393a014