3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoic acid

Base Information

• Chemical Name: 3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoic acid
• CAS No.: 1097777-58-6
• Molecular Formula: C₁₅H₁₅Cl₂NO₃
• Molecular Weight: 328.195

Synonyms:3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoic acid

Chemical Property of 3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoic acid

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Technology Process of 3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoic acid

There total 1 articles about 3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

cycl-isopropylidene malonate (2033-24-1) + 3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carbaldehyde (1020570-56-2) → 3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoic acid (1097777-58-6)

Guidance literature:

cycl-isopropylidene malonate; 3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carbaldehyde; With triethylamine; In N,N-dimethyl-formamide; at 95 - 100 ℃; for 5h; formate buffer; Inert atmosphere;

With hydrogenchloride; water; at 20 ℃; pH=1;

DOI:10.1016/j.bmcl.2009.06.062

Reference yield:

ethyl 3-[(3-amino-2-hydroxyphenyl)amino]benzoate (1097777-70-2) + 3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoic acid (1097777-58-6) → ethyl 3-{[3-({3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoyl}amino)-2-hydroxyphenyl]amino}benzoate (1097777-71-3)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetonitrile; at 20 ℃; for 20h;

Reference yield:

3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoic acid (1097777-58-6) + isobutyl chloroformate (543-27-1) → C20H23Cl2NO5

Guidance literature:

With triethylamine; In dichloromethane; at -15 - -5 ℃;

upstream raw materials:

cycl-isopropylidene malonate

3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carbaldehyde

Downstream raw materials:

ethyl 3-{[3-({3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoyl}amino)-2-hydroxyphenyl]amino}benzoate

methyl 3'-({3-[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]propanoyl}amino)-4'-hydroxy-3-biphenylcarboxylate

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