5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid

Base Information

Chemical Name:5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid
CAS No.:1418274-55-1
Molecular Formula:C₃₀H₂₈Cl₃N₃O₅
Molecular Weight:616.928
Hs Code.:

5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid

Synonyms:5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid

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Chemical Property of 5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid

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Technology Process of 5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid

There total 25 articles about 5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1418274-69-7
ethyl 5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylate

: 1418274-55-1
5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 4.5h;

Reference yield:

: 15760-35-7
3-methylenecyclobutanecarbonitrile

: 1418274-55-1
5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether / 20 °C / Cooling with ice

2.1: sodium ethanolate / diethyl ether; ethanol / 0.25 h / 20 °C

2.2: 4.5 h / 67 °C

3.1: ethanol / 3 h / 20 °C

4.1: ruthenium(III) trichloride hydrate; sodium periodate / water; acetonitrile / 0.75 h / 20 °C / Cooling with ice

5.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 4.25 h / 20 °C / Cooling with ice

5.2: 1.5 h / -10 - 20 °C

6.1: lithium hydroxide monohydrate / tetrahydrofuran; water; methanol / 4.5 h / 20 °C

With sodium periodate; lithium hydroxide monohydrate; ruthenium(III) trichloride hydrate; isopropylmagnesium chloride; sodium ethanolate; lithium chloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetonitrile;

Reference yield:

: 15760-35-7
3-methylenecyclobutanecarbonitrile

: 1418274-55-1
5-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylic acid

: 1418274-56-2
5-((1r,3r)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-1-isopropyl-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether / 20 °C / Cooling with ice

2.1: sodium ethanolate / diethyl ether; ethanol / 0.25 h / 20 °C

2.2: 4.5 h / 67 °C

3.1: ethanol / 3 h / 20 °C

4.1: ruthenium(III) trichloride hydrate; sodium periodate / water; acetonitrile / 0.75 h / 20 °C / Cooling with ice

5.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 4.25 h / 20 °C / Cooling with ice

5.2: 1.5 h / -10 - 20 °C

6.1: lithium hydroxide monohydrate / tetrahydrofuran; water; methanol / 4.5 h / 20 °C

With sodium periodate; lithium hydroxide monohydrate; ruthenium(III) trichloride hydrate; isopropylmagnesium chloride; sodium ethanolate; lithium chloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetonitrile;