α(S)-amino-4-hydroxy-N-<1(R)-(hydroxymethyl)-2-(3-phenylpropoxy)ethyl>-2,6-dimekthylbenzenepropanamide hydrochloride

Base Information

Chemical Name:α(S)-amino-4-hydroxy-N-<1(R)-(hydroxymethyl)-2-(3-phenylpropoxy)ethyl>-2,6-dimekthylbenzenepropanamide hydrochloride
CAS No.:137650-37-4
Molecular Formula:C₂₃H₃₂N₂O₄*ClH
Molecular Weight:436.979
Hs Code.:

Synonyms:α(S)-amino-4-hydroxy-N-<1(R)-(hydroxymethyl)-2-(3-phenylpropoxy)ethyl>-2,6-dimekthylbenzenepropanamide hydrochloride

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Chemical Property of α(S)-amino-4-hydroxy-N-<1(R)-(hydroxymethyl)-2-(3-phenylpropoxy)ethyl>-2,6-dimekthylbenzenepropanamide hydrochloride

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Technology Process of α(S)-amino-4-hydroxy-N-<1(R)-(hydroxymethyl)-2-(3-phenylpropoxy)ethyl>-2,6-dimekthylbenzenepropanamide hydrochloride

There total 6 articles about α(S)-amino-4-hydroxy-N-<1(R)-(hydroxymethyl)-2-(3-phenylpropoxy)ethyl>-2,6-dimekthylbenzenepropanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {(S)-2-(4-Hydroxy-2,6-dimethyl-phenyl)-1-[(R)-1-hydroxymethyl-2-(3-phenyl-propoxy)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

: 137650-37-4
α(S)-amino-4-hydroxy-N-<1(R)-(hydroxymethyl)-2-(3-phenylpropoxy)ethyl>-2,6-dimekthylbenzenepropanamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 23 ℃; for 0.166667h; Yield given;
DOI:10.1021/jm00080a005

Reference yield:

: 69804-99-5
3-phenylpropanol methanesulfonate

: 137650-37-4
α(S)-amino-4-hydroxy-N-<1(R)-(hydroxymethyl)-2-(3-phenylpropoxy)ethyl>-2,6-dimekthylbenzenepropanamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, a.) RT, 1 h, b.) 50 deg C, 2 h, 2.) THF, a.) 40 deg C, 16 h, b.) reflux, 2 h

2: 58 percent / 6N aq. H₂SO₄ / 16 h / Heating

3: 4-methylmorpholine / CH₂Cl₂ / 1.5 h

4: 6.5N HCl / dioxane / 0.17 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; sulfuric acid; sodium hydride; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00080a005

Reference yield:

: 99953-00-1,111633-04-6
(S)-N-Boc-2,6-dimethyltyrosine

: 137650-37-4
α(S)-amino-4-hydroxy-N-<1(R)-(hydroxymethyl)-2-(3-phenylpropoxy)ethyl>-2,6-dimekthylbenzenepropanamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methylmorpholine / tetrahydrofuran / 0.75 h / -23 °C

2: 4-methylmorpholine / CH₂Cl₂ / 1.5 h

3: 6.5N HCl / dioxane / 0.17 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00080a005