Technology Process of (R)-1-{2-[4-(benzylamino)-2-oxopyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid
There total 7 articles about (R)-1-{2-[4-(benzylamino)-2-oxopyridin-1(2H)-yl]acetamido}-3-methylbutylboronic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; Dihydroxy-isobutyl-boran;
In
methanol; hexane; water;
at 20 ℃;
for 18h;
DOI:10.1002/cmdc.201402075
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium hydroxide / ethanol; water / 4 h / 0 - 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -15 - 20 °C
3: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; hexane; water / 18 h / 20 °C
With
hydrogenchloride; Dihydroxy-isobutyl-boran; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
methanol; ethanol; hexane; dichloromethane; water;
DOI:10.1002/cmdc.201402075
- Guidance literature:
-
Multi-step reaction with 5 steps
1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2 h / 20 °C
2: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C
3: lithium hydroxide / ethanol; water / 4 h / 0 - 20 °C
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -15 - 20 °C
5: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; hexane; water / 18 h / 20 °C
With
hydrogenchloride; Dihydroxy-isobutyl-boran; palladium 10% on activated carbon; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201402075