(1S,3R,6aS,9R,10aR,11aS)-1-phenyl-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine

Base Information

Chemical Name:(1S,3R,6aS,9R,10aR,11aS)-1-phenyl-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine
CAS No.:914359-96-9
Molecular Formula:C₂₁H₃₁NO₂
Molecular Weight:329.483
Hs Code.:

Synonyms:(1S,3R,6aS,9R,10aR,11aS)-1-phenyl-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine

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Chemical Property of (1S,3R,6aS,9R,10aR,11aS)-1-phenyl-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine

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Technology Process of (1S,3R,6aS,9R,10aR,11aS)-1-phenyl-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine

There total 3 articles about (1S,3R,6aS,9R,10aR,11aS)-1-phenyl-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 914359-80-1
(1S,3S,6aS,9R,10aR,11aS)-1-phenyl-3-phenylselenenylmethyl-6,6,9-trimethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine

: 914359-96-9
(1S,3R,6aS,9R,10aR,11aS)-1-phenyl-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); triphenylstannane; In toluene; Heating;
DOI:10.1021/jo061547k

Reference yield:

: 848033-71-6
(2S,4aS,7R,8aR)-N-allyl-2-benzoyl-4,4,7-trimethyl-octahydrobenzo[e][1,3]oxazine

: 914359-96-9
(1S,3R,6aS,9R,10aR,11aS)-1-phenyl-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / NaBH₄ / ethanol / 5 h / -10 - 0 °C

2: K₂CO₃ / CH₂Cl₂ / 5 h / 0 °C

3: 94 percent / AIBN; Ph₃SnH / toluene / Heating

With sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); triphenylstannane; potassium carbonate; In ethanol; dichloromethane; toluene;
DOI:10.1021/jo061547k

Reference yield:

: 914359-67-4
(S)-[(2S,4aS,7R,8aR)-3-allyl-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanol

: 914359-96-9
(1S,3R,6aS,9R,10aR,11aS)-1-phenyl-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / CH₂Cl₂ / 5 h / 0 °C

2: 94 percent / AIBN; Ph₃SnH / toluene / Heating

With 2,2'-azobis(isobutyronitrile); triphenylstannane; potassium carbonate; In dichloromethane; toluene;
DOI:10.1021/jo061547k