3-[(R)-8a-((E)-4-Hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3-[(R)-8a-((E)-4-Hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester
CAS No.:124268-83-3
Molecular Formula:C₃₄H₄₁N₃O₆
Molecular Weight:587.716
Hs Code.:

3-[(R)-8a-((E)-4-Hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

Synonyms:3-[(R)-8a-((E)-4-Hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

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Chemical Property of 3-[(R)-8a-((E)-4-Hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

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Technology Process of 3-[(R)-8a-((E)-4-Hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

There total 12 articles about 3-[(R)-8a-((E)-4-Hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87-52-5
3-(Dimethylaminomethyl)indole

: 124268-83-3
3-[(R)-8a-((E)-4-Hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / tri-n-butylphosphine / acetonitrile / 7 h / Heating

2: 78 percent / lithium chloride, H₂O / hexamethylphosphoric acid triamide / 2 h / 100 - 105 °C

With tributylphosphine; water; lithium chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; acetonitrile;

Reference yield:

: 81286-83-1
(2R,5R)-5-allyl-2-tert-butyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one

: 124268-83-3
3-[(R)-8a-((E)-4-Hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -78 deg C, 1.5 h

2: 1.) K₂CO₃, 2.) 50percent aq. NaOH / 1.) methylene chloride, 0 deg C, 1 h, 2.) 8 h

3: 1.) ozone, 2.) dimethyl sulfide / 1.) MeOH, -78 deg C, 1 h

4: 1,2-dichloro-benzene / 3 h / 115 °C

5: 96.5 percent / NaBH₄ / ethanol / 0.33 h / 35 - 50 °C

6: triethylamine / dimethylformamide / 1 h / Ambient temperature

7: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 2.) -78 deg C, 20 min

8: 62 percent / tri-n-butylphosphine / acetonitrile / 7 h / Heating

9: 78 percent / lithium chloride, H₂O / hexamethylphosphoric acid triamide / 2 h / 100 - 105 °C

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; dimethylsulfide; tributylphosphine; water; potassium carbonate; ozone; triethylamine; lithium chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetonitrile;

Reference yield:

: 116005-51-7
(-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine

: 124268-83-3
3-[(R)-8a-((E)-4-Hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) K₂CO₃, 2.) 50percent aq. NaOH / 1.) methylene chloride, 0 deg C, 1 h, 2.) 8 h

2: 1.) ozone, 2.) dimethyl sulfide / 1.) MeOH, -78 deg C, 1 h

3: 1,2-dichloro-benzene / 3 h / 115 °C

4: 96.5 percent / NaBH₄ / ethanol / 0.33 h / 35 - 50 °C

5: triethylamine / dimethylformamide / 1 h / Ambient temperature

6: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 2.) -78 deg C, 20 min

7: 62 percent / tri-n-butylphosphine / acetonitrile / 7 h / Heating

8: 78 percent / lithium chloride, H₂O / hexamethylphosphoric acid triamide / 2 h / 100 - 105 °C

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; dimethylsulfide; tributylphosphine; water; potassium carbonate; ozone; triethylamine; lithium chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetonitrile;