N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2,4-difluorobenzyl)semicarbazide

Base Information

• Chemical Name: N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2,4-difluorobenzyl)semicarbazide
• CAS No.: 1491173-75-1
• Molecular Formula: C₃₃H₃₆F₃N₅O₄
• Molecular Weight: 623.675

Synonyms:N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2,4-difluorobenzyl)semicarbazide

Chemical Property of N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2,4-difluorobenzyl)semicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2,4-difluorobenzyl)semicarbazide

There total 12 articles about N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2,4-difluorobenzyl)semicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.1%

(E)-N4-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline-4-yloxy)phenyl)-N1-(2,4-difluorobenzylidene)semicarbazide (1428787-71-6) → N1-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N4-(2,4-difluorobenzyl)semicarbazide (1491173-75-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; acetic acid; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2013.06.026

Reference yield:

4-(3-chloropropoxy)-3-methoxyacetophenone (58113-30-7) → N1-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N4-(2,4-difluorobenzyl)semicarbazide (1491173-75-1)

Guidance literature:

Multi-step reaction with 11 steps

1: nitric acid / dichloromethane / 2 h / -10 °C

2: toluene / 110 °C

3: iron / acetic acid / 2 h / 40 - 80 °C

4: acetonitrile / 8 h / 25 - 80 °C

5: trichlorophosphate / acetonitrile / Reflux

6: chlorobenzene / 20 h / 140 °C

7: iron; hydrogenchloride / ethanol; water / 2 h / Reflux

8: potassium carbonate / acetone / 3 h / 0 - 20 °C

9: hydrazine hydrate / 1,4-dioxane / Reflux

10: acetic acid / isopropyl alcohol / Reflux

11: sodium tris(acetoxy)borohydride / acetic acid; tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; nitric acid; sodium tris(acetoxy)borohydride; iron; potassium carbonate; hydrazine hydrate; acetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetic acid; chlorobenzene; isopropyl alcohol; acetone; toluene; acetonitrile;

DOI:10.1016/j.bmc.2013.06.026

Reference yield:

1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one (1160707-44-7) → N1-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N4-(2,4-difluorobenzyl)semicarbazide (1491173-75-1)

Guidance literature:

Multi-step reaction with 10 steps

1: toluene / 110 °C

2: iron / acetic acid / 2 h / 40 - 80 °C

3: acetonitrile / 8 h / 25 - 80 °C

4: trichlorophosphate / acetonitrile / Reflux

5: chlorobenzene / 20 h / 140 °C

6: iron; hydrogenchloride / ethanol; water / 2 h / Reflux

7: potassium carbonate / acetone / 3 h / 0 - 20 °C

8: hydrazine hydrate / 1,4-dioxane / Reflux

9: acetic acid / isopropyl alcohol / Reflux

10: sodium tris(acetoxy)borohydride / acetic acid; tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; iron; potassium carbonate; hydrazine hydrate; acetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetic acid; chlorobenzene; isopropyl alcohol; acetone; toluene; acetonitrile;

DOI:10.1016/j.bmc.2013.06.026

upstream raw materials:

4-(3-chloropropoxy)-3-methoxyacetophenone

(E)-N⁴-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline-4-yloxy)phenyl)-N¹-(2,4-difluorobenzylidene)semicarbazide

1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1491173-75-1 N¹-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-N⁴-(2,4-difluorobenzyl)semicarbazide

Send

Send

Metric Ton KG G Pound L ML

Send

Send