{2-[2-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionylamino]-phenyl}-propynoic acid methyl ester

Base Information

Chemical Name:{2-[2-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionylamino]-phenyl}-propynoic acid methyl ester
CAS No.:97387-48-9
Molecular Formula:C₁₉H₂₂N₂O₃
Molecular Weight:326.395
Hs Code.:

Synonyms:{2-[2-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionylamino]-phenyl}-propynoic acid methyl ester

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Chemical Property of {2-[2-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionylamino]-phenyl}-propynoic acid methyl ester

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Technology Process of {2-[2-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionylamino]-phenyl}-propynoic acid methyl ester

There total 6 articles about {2-[2-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionylamino]-phenyl}-propynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionyl chloride

: 97387-41-2
methyl 3-(2-aminophenyl)prop-2-ynoate

: 97387-48-9
{2-[2-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionylamino]-phenyl}-propynoic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2015.11.060

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 97387-48-9
{2-[2-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionylamino]-phenyl}-propynoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / NaH / diethyl ether / Heating

2: 100 percent / LDA / tetrahydrofuran / 1 h / -68 °C

3: KOH / H₂O / 2 h / 60 °C

4: (CH₃)2CC(Cl)N(CH₃)2 / CH₂Cl₂ / 20 °C

5: triethylamine

With potassium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium hydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4039(00)98574-5

Reference yield:

: 97387-47-8
2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)propanoic acid

: 97387-48-9
{2-[2-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionylamino]-phenyl}-propynoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (CH₃)2CC(Cl)N(CH₃)2 / CH₂Cl₂ / 20 °C

2: triethylamine

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)98574-5