(2R,3S)-2-hydroxy-4-methyl-3-phenylsulfanylcarbonylpentanoic acid

Base Information

• Chemical Name: (2R,3S)-2-hydroxy-4-methyl-3-phenylsulfanylcarbonylpentanoic acid
• CAS No.: 1391040-81-5
• Molecular Formula: C₁₃H₁₆O₄S
• Molecular Weight: 268.334
• Mol file: 1391040-81-5.mol

Synonyms:(2R,3S)-2-hydroxy-4-methyl-3-phenylsulfanylcarbonylpentanoic acid

Chemical Property of (2R,3S)-2-hydroxy-4-methyl-3-phenylsulfanylcarbonylpentanoic acid

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3S)-2-hydroxy-4-methyl-3-phenylsulfanylcarbonylpentanoic acid

There total 1 articles about (2R,3S)-2-hydroxy-4-methyl-3-phenylsulfanylcarbonylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ethyl (2R,3S)-2-hydroxy-4-methyl-3-phenylsulfanylcarbonylpentanoate → (2R,3S)-2-hydroxy-4-methyl-3-phenylsulfanylcarbonylpentanoic acid (1391040-81-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 55 - 60 ℃; for 50h; Inert atmosphere;

DOI:10.1039/c2ob25586c

Reference yield: 38.0%

3,5-dimethoxybenzylamine (34967-24-3) + (2R,3S)-2-hydroxy-4-methyl-3-phenylsulfanylcarbonylpentanoic acid (1391040-81-5) → (2R,3S)-N-(3,5-dimethoxybenzyl)-3-isopropyl-4-oxooxetane-2-carboxamide (1029997-39-4)

Guidance literature:

With 2,4,6-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -30 - 20 ℃; for 36h; Inert atmosphere;

DOI:10.1039/c2ob25586c

Downstream raw materials:

(2R,3S)-N-(3,5-dimethoxybenzyl)-3-isopropyl-4-oxooxetane-2-carboxamide