4-(7-(5-(piperidin-1-ylmethyl)thiophen-3-yl)pyrido[3,2-d]pyrimidin-2-yl)phenol

Base Information

Chemical Name:4-(7-(5-(piperidin-1-ylmethyl)thiophen-3-yl)pyrido[3,2-d]pyrimidin-2-yl)phenol
CAS No.:1345956-61-7
Molecular Formula:C₂₃H₂₂N₄OS
Molecular Weight:402.52
Hs Code.:

Synonyms:4-(7-(5-(piperidin-1-ylmethyl)thiophen-3-yl)pyrido[3,2-d]pyrimidin-2-yl)phenol

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Chemical Property of 4-(7-(5-(piperidin-1-ylmethyl)thiophen-3-yl)pyrido[3,2-d]pyrimidin-2-yl)phenol

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Technology Process of 4-(7-(5-(piperidin-1-ylmethyl)thiophen-3-yl)pyrido[3,2-d]pyrimidin-2-yl)phenol

There total 2 articles about 4-(7-(5-(piperidin-1-ylmethyl)thiophen-3-yl)pyrido[3,2-d]pyrimidin-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345955-99-8
7-chloro-2-(4-hydroxyphenyl)-pyrido[3,2-d]pyrimidine

: 1345956-75-3
C₁₀H₁₆BNO₂S

: 1345956-61-7
4-(7-(5-(piperidin-1-ylmethyl)thiophen-3-yl)pyrido[3,2-d]pyrimidin-2-yl)phenol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 150 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.ejmech.2014.04.055

Reference yield:

: 110-89-4
piperidine

: 175592-59-3
(5‐formylthiophen‐3‐yl)boronic acid

: 1345956-61-7
4-(7-(5-(piperidin-1-ylmethyl)thiophen-3-yl)pyrido[3,2-d]pyrimidin-2-yl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 1,2-dimethoxyethane / 0.08 h / 20 °C

1.2: 5 h / 60 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; In 1,2-dimethoxyethane; ethanol; toluene; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.ejmech.2014.04.055